Difference between revisions of "WalR"

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(Extended information on the protein)
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* '''Effectors of protein activity:''' phosphorylation likely affects DNA-binding activity
 
* '''Effectors of protein activity:''' phosphorylation likely affects DNA-binding activity
  
* '''Interactions:''' [[WalK]]-[[WalR]]
+
* '''[[SubtInteract|Interactions]]:'''
 +
** [[WalK]]-[[WalR]]
  
* '''Localization:''' cytoplasm (according to Swiss-Prot)
+
* '''[[Localization]]:''' cytoplasm (according to Swiss-Prot)
  
 
=== Database entries ===
 
=== Database entries ===

Revision as of 12:31, 10 August 2011

  • Description: two-component response regulator, controls cell wall metabolism

Gene name walR
Synonyms yycF
Essential yes PubMed
Product two-component response regulator
Function control of cell wall metabolism
Interactions involving this protein in SubtInteract: WalR
MW, pI 27 kDa, 4.876
Gene length, protein length 705 bp, 235 aa
Immediate neighbours walK, trnY-Phe
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YycF context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

cell wall/ other, transcription factors and their control, essential genes, phosphoproteins

This gene is a member of the following regulons

The WalR regulon

The gene

Basic information

  • Locus tag: BSU40410

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: OmpR family of two-component transcription regulators
  • Paralogous protein(s):


Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated by WalK on an Asp residue
  • Cofactor(s):
  • Effectors of protein activity: phosphorylation likely affects DNA-binding activity

Database entries

  • Structure: 2D1V (DNA binding domain), 2ZWM (receiver domain)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: expressed during vegetative growth, repressed during stationary phase PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

The WalR regulon

Paola Bisicchia, David Noone, Efthimia Lioliou, Alistair Howell, Sarah Quigley, Thomas Jensen, Hanne Jarmer, Kevin M Devine
The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis.
Mol Microbiol: 2007, 65(1);180-200
[PubMed:17581128] [WorldCat.org] [DOI] (P p)

Alistair Howell, Sarah Dubrac, Kasper Krogh Andersen, David Noone, Juliette Fert, Tarek Msadek, Kevin Devine
Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach.
Mol Microbiol: 2003, 49(6);1639-55
[PubMed:12950927] [WorldCat.org] [DOI] (P p)

Keisuke Fukuchi, Yasuhiro Kasahara, Kei Asai, Kazuo Kobayashi, Shigeki Moriya, Naotake Ogasawara
The essential two-component regulatory system encoded by yycF and yycG modulates expression of the ftsAZ operon in Bacillus subtilis.
Microbiology (Reading): 2000, 146 ( Pt 7);1573-1583
[PubMed:10878122] [WorldCat.org] [DOI] (P p)

Other original Publications