Difference between revisions of "SubtInteract"
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=== [[metabolism]]: the metabolons of glycolysis and the TCA cycle {{PubMed|19193632,20933603}}=== | === [[metabolism]]: the metabolons of glycolysis and the TCA cycle {{PubMed|19193632,20933603}}=== | ||
| − | ==Suspected hub proteins potentially involved in a large number of interactions== | + | ==Suspected hub proteins potentially involved in a large number of interactions (as deduced from a Yeast two-hybrid analysis)== |
| + | * [[FruA]], [SwrC], [[XhlA]], [[YhaP]], [[YhgE]], [[YkcC]], [[YqfF]], [[CsbC]], [[CssS]], [[FliZ]], [[MreD]], [[PpsC]], [[RacA]], [[Smc]], [[YclI]], [[YdeL]], [[YdgH]], [[YdbI]], [[YesS]], [[YkoT]], [[YopZ]], [[YqbD]], [[YtdP]], [[YueB]], [[YwqJ]], [[YyxA]] | ||
<pubmed> 21630458</pubmed> | <pubmed> 21630458</pubmed> | ||
==Important publications== | ==Important publications== | ||
<pubmed>20658969 18228443 18219467 17953394 15264234 14706816 12127457 11827824 11377797 11306254 10851163 10842303 18366733 10694888 2200717 2441660 20969605 15451506 </pubmed> | <pubmed>20658969 18228443 18219467 17953394 15264234 14706816 12127457 11827824 11377797 11306254 10851163 10842303 18366733 10694888 2200717 2441660 20969605 15451506 </pubmed> | ||
Revision as of 19:49, 16 June 2011
Protein-protein interactions are essential for many activities of any living cell. These interactions involve multi-protein complexes that take part in central processes such as DNA replication, transcription or translation. Protein-protein interactions may also be involved in a variety of regulatory events. Metabolic enzymes do often form transien complexes that represent a complete pathways. These complexes are called metabolon. Finally, many interactions may be of a transient nature.
Contents
- 1 Methods to detect protein-protein interactions
- 2 Visualization of protein-protein interactions in B. subtilis
- 3 Protein complexes in B. subtilis
- 3.1 DNA replication: the replisome
- 3.2 transcription: RNA polymerase
- 3.3 translation: the ribosome
- 3.4 synthesis of glutamyl-tRNA(Gln): the transamidosome (GatA-GatB-GatC)-GltX-trnS-Gln
- 3.5 RNA processing and degradation: the RNA degradosome
- 3.6 general stress response: the stressosome
- 3.7 cell division: the divisome
- 3.8 DNA uptake: the pseudopilus PubMed
- 3.9 metabolism: the metabolons of glycolysis and the TCA cycle PubMed
- 4 Suspected hub proteins potentially involved in a large number of interactions (as deduced from a Yeast two-hybrid analysis)
- 5 Important publications
Methods to detect protein-protein interactions
- Yeast Two Hybrid System PubMed
- TAP-Tag purification PubMed
Attention: Each technique detects only about 33% of all interactions PubMed
Visualization of protein-protein interactions in B. subtilis
- interactive protein-protein interaction map
- the beta version of SubtInteract
Protein complexes in B. subtilis
DNA replication: the replisome
transcription: RNA polymerase
translation: the ribosome
synthesis of glutamyl-tRNA(Gln): the transamidosome (GatA-GatB-GatC)-GltX-trnS-Gln
RNA processing and degradation: the RNA degradosome
general stress response: the stressosome
cell division: the divisome
DNA uptake: the pseudopilus PubMed
metabolism: the metabolons of glycolysis and the TCA cycle PubMed
Suspected hub proteins potentially involved in a large number of interactions (as deduced from a Yeast two-hybrid analysis)
- FruA, [SwrC], XhlA, YhaP, YhgE, YkcC, YqfF, CsbC, CssS, FliZ, MreD, PpsC, RacA, Smc, YclI, YdeL, YdgH, YdbI, YesS, YkoT, YopZ, YqbD, YtdP, YueB, YwqJ, YyxA
Elodie Marchadier, Rut Carballido-López, Sophie Brinster, Céline Fabret, Peggy Mervelet, Philippe Bessières, Marie-Françoise Noirot-Gros, Vincent Fromion, Philippe Noirot
An expanded protein-protein interaction network in Bacillus subtilis reveals a group of hubs: Exploration by an integrative approach.
Proteomics: 2011, 11(15);2981-91
[PubMed:21630458]
[WorldCat.org]
[DOI]
(I p)
Important publications
