Difference between revisions of "MetE"
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=== Additional information=== | === Additional information=== | ||
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* '''Domains:''' | * '''Domains:''' | ||
| − | * '''Modification:''' phosphorylated on ser/ thr/ tyr [http://www.ncbi.nlm.nih.gov/pubmed/17726680 PubMed], S-cysteinylation after diamide stress (C719) [http://www.ncbi.nlm.nih.gov/sites/entrez/17611193 PubMed] | + | * '''Modification:''' |
| + | **phosphorylated on ser/ thr/ tyr [http://www.ncbi.nlm.nih.gov/pubmed/17726680 PubMed], S-cysteinylation after diamide stress (C719) [http://www.ncbi.nlm.nih.gov/sites/entrez/17611193 PubMed] | ||
| + | ** S-bacillithiolation upon hypochlorite stress on Cys-730 {{PubMed|21749987}} | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
* '''Localization:''' | * '''Localization:''' | ||
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=References= | =References= | ||
| − | <pubmed>19258532,16194229,10094622,17611193,18039762 ,17726680 12107147, </pubmed> | + | <pubmed>19258532,16194229,10094622,17611193,18039762 ,17726680 12107147, 21749987</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 08:28, 14 July 2011
- Description: methionine synthase
| Gene name | metE |
| Synonyms | metC |
| Essential | no |
| Product | methionine synthase |
| Function | biosynthesis of methionine |
| Metabolic function and regulation of this protein in SubtiPathways: Cys, Met & Sulfate assimilation | |
| MW, pI | 86 kDa, 4.839 |
| Gene length, protein length | 2286 bp, 762 aa |
| Immediate neighbours | guaD, ispA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU13180
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine (according to Swiss-Prot)
- Protein family: vitamin-B12 independent methionine synthase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- UniProt: P80877
- KEGG entry: [2]
- E.C. number: 2.1.1.14
Additional information
- subject to Clp-dependent proteolysis upon glucose starvation PubMed
Expression and regulation
- Operon: metE
- Regulation:
- Regulatory mechanism: S-box: transcription termination/ antitermination, the S-box riboswitch binds S-adenosylmethionine resulting in termination PubMed
- Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
