Alr

• Description: alanine racemase
  
  

Gene name	alr
Synonyms	dal, alrA
Essential	yes PubMed
Product	alanine racemase
Function	peptidoglycan biosynthesis
MW, pI	43 kDa, 8.431
Gene length, protein length	1167 bp, 389 aa
Immediate neighbours	ydcC, ndoAI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU04640

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: L-alanine = D-alanine (according to Swiss-Prot)

• Protein family: alanine racemase family (according to Swiss-Prot)

• Paralogous protein(s): YncD

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1L6G (with N-[5�-phosphopyridoxyl]-D-alanine, Geobacillus stearothermophilus), 1SFT (Geobacillus stearothermophilus)

• UniProt: P10725

• KEGG entry: [2]

• E.C. number: 5.1.1.1

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

M P Heaton, R B Johnston, T L Thompson
Controlled lysis of bacterial cells utilizing mutants with defective synthesis of D-alanine.
Can J Microbiol: 1988, 34(3);256-61
[PubMed:3138014] [WorldCat.org] [DOI] (P p)