ArsR

• Description: arsenic resistance operon repressor
  
  

Gene name	arsR
Synonyms	yqcJ
Essential	no
Product	transcription repressor
Function	regulation of as (III) efflux
MW, pI	12 kDa, 4.883
Gene length, protein length	315 bp, 105 aa
Immediate neighbours	yqcK, yqcI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU25810

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P45949

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:
  • repressed in the absence of toxic metal ions (As(III), Cd(II) and Ag(I)) (ArsR) PubMed

• Regulatory mechanism:
  • ArsR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947] [WorldCat.org] [DOI] (P p)

T Sato, Y Kobayashi
The ars operon in the skin element of Bacillus subtilis confers resistance to arsenate and arsenite.
J Bacteriol: 1998, 180(7);1655-61
[PubMed:9537360] [WorldCat.org] [DOI] (P p)