lytH

lytH
168

differentiation-associated peptidoglycan hydrolase involved in endospore cortex maturation

Locus
BSU_32340
Molecular weight
39.48 kDa
Isoelectric point
6.89
Protein length
Gene length
Function
endospore cortex maturation
Product
peptidoglycan hydrolase
Essential
no
Synonyms
lytH, yunA, yutA

Genomic Context

List of homologs in different organisms, belongs to COG0739 (Galperin et al., 2021)

This gene is a member of the following regulons

SigK regulon

Gene
Coordinates
3,321,455  3,322,435
The protein
Catalyzed reaction/ biological activity
cleaves the peptide bond between L-Ala (position 1 in the peptioglycan peptide) and D-Glu (position 2) PubMed
Protein family
peptidase M23B family (single member, according to UniProt)
Structure
3NYY (PDB) (from Ruminococcus gnavus, the C-terminal peptidase M23 domain, aa 178 ... 315, 46% identity)
Expression and Regulation
Operons
Genes
Description
Regulation
expressed late during sporulation in the mother cell (SigK) PubMed
Sigma factors
SigK: sigma factor, PubMed, in sigK regulon
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lytH

2025-01-14 18:38:41

ghost

68

1a84c1b186da1ad850397557ac1d1127e38e2843

3009CC9AFBB587E816A7A56514B6623579929A99

Biological materials
Mutant
MGNA-B579 (yunA::erm), available at the NBRP B. subtilis, Japan
BKE32340 (lytH::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CACAAAATAATCTCCTTTCA,  downstream forward: _UP4_TAACAAAAAGCCGCCTCTTC
BKK32340 (lytH::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CACAAAATAATCTCCTTTCA,  downstream forward: _UP4_TAACAAAAAGCCGCCTCTTC
References
Reviews
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Original Publications
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11AF08158121DEDFDDC0F64C52EFF3CF3AE30CE6

Page visits: 2599

Time of last update: 2025-01-25 13:41:45

Author of last update: Jstuelk