ytpB

ytpB
168

tetraprenyl-beta-curcumene synthase, catalyzes the first committed step in C35 terpenoid biosynthesis, salt stress protein

Locus
BSU_30500
Molecular weight
42.68 kDa
Isoelectric point
5.76
Protein length
Gene length
Function
C35 terpenoid biosynthesis
Product
tetraprenyl-beta-curcumene synthase
Essential
no
Synonyms
ytpB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
3,121,538  3,122,641
Phenotypes of a mutant
increased sensitivity to bacitracin, due to the accumulation of heptaprenyl pyrophosphate PubMed
sensitivity is increased in a ''ytpB menA'' double mutant PubMed
The protein
Catalyzed reaction/ biological activity
all-trans-heptaprenyl diphosphate --> diphosphate + tetraprenyl-β-curcumene (according to UniProt)
Structure
5YO8 (PDB) (from Bacillus alcalophilus, 50% identity)
Expression and Regulation
Operons
Genes
Description
Regulation
expressed under conditions of salt stress (SigM) Pubmed
Sigma factors
SigM: sigma factor, PubMed, in sigM regulon
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ytpB

2025-01-17 10:10:20

ghost

77

23ddcbad6caff5f39cf360301ad71dc26adb11dc

05895221D119203F060ADC02BC219DB5217090D2

Genes
Description
Regulation
expressed under conditions of salt stress (SigM) PubMed
induced by cell wall-inhibiting drugs, such as bacitracin and cefuroxime (SigM) PubMed
Sigma factors
SigM: sigma factor, PubMed, in sigM regulon
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ytpAytpB

2025-01-16 08:16:20

Jstuelk

78

41A293118D974BA8F373EA72D3616B1F31A4B6E6

6E9DEAC29839E036AE05C9AB94BA1EAB44ED7718

Biological materials
Mutant
MGNA-A164 (ytpB::erm), available at the NBRP B. subtilis, Japan
BKE30500 (ytpB::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CAACACATGCACCCCCTACT,  downstream forward: _UP4_AAAAATTCAAAGAAAAAAGC
BKK30500 (ytpB::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CAACACATGCACCCCCTACT,  downstream forward: _UP4_AAAAATTCAAAGAAAAAAGC
References
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596C09DD1D9C305B7C49B2F5E90E2C6C33F63D0E

Page visits: 4508

Time of last update: 2025-01-17 17:38:17

Author of last update: Jstuelk