asd

asd
168

aspartate-semialdehyde dehydrogenase

Locus
BSU_16750
Molecular weight
37.69 kDa
Isoelectric point
4.97
Protein length
346 aaSequenceBlast
Gene length
1041 bpSequenceBlast
Function
biosynthesis of threonine, lysine, dipicolic acid, peptidoglycan
Product
aspartate-semialdehyde dehydrogenase
Essential
yes
E.C.
1.2.1.11
Synonyms
asd
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG0136 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,745,991  1,747,031
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
L-aspartate 4-semialdehyde + NADP+ + phosphate --> 4-phospho-L-aspartate + H+ + NADPH (according to UniProt)
Protein family
aspartate-semialdehyde dehydrogenase family (single member, according to UniProt)
Structure
2GYY (PDB) (from Streptococcus pneumoniae, 52% identity, 65% similarity) PubMed
Q04797 (AlphaFold)
Modification
phosphorylation on Ser-98 AND Tyr-146 PubMed
Expression and Regulation
Operons
Genes
asd-dapG-dapA
Description
PubMed
Sigma factors
SigK: sigma factor, PubMed, in sigK regulon
SigA: sigma factor, PubMed, in sigA regulon
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asd→dapA

2025-03-16 18:45:11

ghost

101

26b99709bb2d46d49ca998bee33208e722bad3f7

5716FEABC6E16C3675FEA484CEBA95D8F93F13D1

Genes
spoVFA-spoVFB-asd-dapG-dapA
Description
PubMed
Regulation
expressed late during sporulation in the mother cell (SigK) PubMed
Sigma factors
SigK: sigma factor, PubMed, in sigK regulon
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spoVFA→dapA

2025-03-21 22:03:33

ghost

250

9f1758bf801d23548827e9d03f6ca9d0c2e6746d

C373CB045AB9232B86B60761B90C3510E98A06A8

References
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Page visits: 4081

Time of last update: 2025-04-06 00:25:13

Author of last update: Melvin.boenninger