secY
168
preprotein translocase subunit, universally conserved protein
Locus
BSU_01360
Molecular weight
47.08 kDa
Isoelectric point
10.21
Function
protein secretion
Product
preprotein translocase subunit
Essential
yes
Synonyms
secY
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0201 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
144,527 145,822
Phenotypes of a mutant
The protein
Protein family
secY/SEC61-alpha family (single member, according to UniProt)
Structure
membrane PubMed
Additional information
Expression and Regulation
Operons
Description
NULL
Regulation
Regulatory mechanism
stringent response: negative regulation, in stringent response
Sigma factors
SigA: sigma factor, PubMed (two promoters, about 140bp and 200bp upstream of the start codon), in sigA regulon
Additional information
strongly expressed
Genes
Description
Regulation
strongly repressed in response to glucose starvation in M9 medium PubMed
likely autorepression of operon expression upon binding of excess of one ribosomal protein to the untranslated region of the mRNA PubMed
expression is reduced in motile cells as compared to non-motile cells PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
Sigma factors
SigA: sigma factor, PubMed (two promoters, about 140bp and 200bp upstream of the start codon), in sigA regulon
Additional information
term-seq has identified a potential novel regulatory RNA element (protein-dependent leader) including an intrinsic transcription terminator upstream of rpsJ PubMed
Biological materials
Mutant
Pspac-secY PubMed
BEC01360, a CRISPRi knockdown mutant, is available from the Bacillus Genetic Stock Center
References
Reviews
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Original Publications
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Time of last update: 2025-04-21 14:22:21
Author of last update: Melvin.boenninger