Difference between revisions of "L-box"
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| − | + | The L-box is a [[riboswitch]] that binds lysine and controls gene expression by a termination/ antitermination mechanism. Upon binding of lysine, the L-box adopts a terminator structure thtus preventing expression of ''[[lysC]]''. In the absence of lysine, the L-box has an antiterminator structure that allows ''[[lysC]]'' expression and thus lysine biosynthesis. | |
| − | 14523230 | + | ==Gene controlled by a L-box mechanism== |
| + | |||
| + | * ''[[lysC]]'' | ||
| + | * ''[[yvsH]]'' (predicted) | ||
| + | |||
| + | ==References== | ||
| + | <pubmed> 14523230, 17143270 ,14597663 14627808 21169337 22416067 23067368 14627808 </pubmed> | ||
| + | |||
| + | =See also:= | ||
| + | * [[RNA switch]] | ||
| + | |||
| + | =Back to [[regulons]]= | ||
Latest revision as of 13:09, 28 November 2013
The L-box is a riboswitch that binds lysine and controls gene expression by a termination/ antitermination mechanism. Upon binding of lysine, the L-box adopts a terminator structure thtus preventing expression of lysC. In the absence of lysine, the L-box has an antiterminator structure that allows lysC expression and thus lysine biosynthesis.
Gene controlled by a L-box mechanism
References
Larry R Fiegland, Andrew D Garst, Robert T Batey, David J Nesbitt
Single-molecule studies of the lysine riboswitch reveal effector-dependent conformational dynamics of the aptamer domain.
Biochemistry: 2012, 51(45);9223-33
[PubMed:23067368]
[WorldCat.org]
[DOI]
(I p)
Sharnise N Wilson-Mitchell, Frank J Grundy, Tina M Henkin
Analysis of lysine recognition and specificity of the Bacillus subtilis L box riboswitch.
Nucleic Acids Res: 2012, 40(12);5706-17
[PubMed:22416067]
[WorldCat.org]
[DOI]
(I p)
Simon Blouin, Raja Chinnappan, Daniel A Lafontaine
Folding of the lysine riboswitch: importance of peripheral elements for transcriptional regulation.
Nucleic Acids Res: 2011, 39(8);3373-87
[PubMed:21169337]
[WorldCat.org]
[DOI]
(I p)
Kenneth F Blount, Joy Xin Wang, Jinsoo Lim, Narasimhan Sudarsan, Ronald R Breaker
Antibacterial lysine analogs that target lysine riboswitches.
Nat Chem Biol: 2007, 3(1);44-9
[PubMed:17143270]
[WorldCat.org]
[DOI]
(P p)
Dmitry A Rodionov, Alexey G Vitreschak, Andrey A Mironov, Mikhail S Gelfand
Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?
Nucleic Acids Res: 2003, 31(23);6748-57
[PubMed:14627808]
[WorldCat.org]
[DOI]
(I p)
Narasimhan Sudarsan, J Kenneth Wickiser, Shingo Nakamura, Margaret S Ebert, Ronald R Breaker
An mRNA structure in bacteria that controls gene expression by binding lysine.
Genes Dev: 2003, 17(21);2688-97
[PubMed:14597663]
[WorldCat.org]
[DOI]
(P p)
Frank J Grundy, Susan C Lehman, Tina M Henkin
The L box regulon: lysine sensing by leader RNAs of bacterial lysine biosynthesis genes.
Proc Natl Acad Sci U S A: 2003, 100(21);12057-62
[PubMed:14523230]
[WorldCat.org]
[DOI]
(P p)
