truA

truA
168

pseudouridylate synthase I, universally conserved protein

Locus
BSU_01480
Molecular weight
27.90 kDa
Isoelectric point
6.65
Protein length
Gene length
Function
tRNA modification
Product
pseudouridylate synthase I
Essential
no
E.C.
5.4.99.12
Synonyms
truA, ybaH

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0101 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
152,937  153,680
The protein
Catalyzed reaction/ biological activity
tRNA uridine38-40 --> tRNA pseudouridine38-40 (according to UniProt)
Protein family
tRNA pseudouridine synthase TruA family (single member, according to UniProt)
Structure
1VS3 (PDB) (from Thermus thermophilus, 42% identity) PubMed
Additional information
Expression and Regulation
Operons
Description
Regulation
Rel dependent downregulation (Class I) during stringent response PubMed
expression is reduced in motile cells as compared to non-motile cells PubMed
Regulatory mechanism
stringent response: negative regulation, PubMed, in stringent response
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truA->rpsI

2025-01-15 16:35:16

Jstuelk

98

9378802F22213CCB249C12ED6C7E38294E94AEBA

BCBF9D5540A2F40C69EB9BD2FDE789D8B342DBAE

Biological materials
Mutant
BKE01480 (truA::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATACAGCACCTCTAAGCCC,  downstream forward: _UP4_TAAACCAGGTGTATAATATT
BKK01480 (truA::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATACAGCACCTCTAAGCCC,  downstream forward: _UP4_TAAACCAGGTGTATAATATT
References
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84334531D66BE7524021C4B40C3FA05AAFE0D7A6

Page visits: 3493

Time of last update: 2025-01-25 23:54:50

Author of last update: Melvin.boenninger