iolJ
168
2-deoxy-5-keto-gluconic acid-6-phosphate aldolase, formation of dihydroxyacetone phosphate and malonic semialdehyde (6th reaction)
Locus
BSU_39670
Molecular weight
31.22 kDa
Isoelectric point
4.85
Function
myo-inositol catabolism
Product
2-deoxy-5-keto-gluconic acid-6-phosphate aldolase, formation of dihydroxyacetone phosphate and malonic semialdehyde (6th reaction)
Essential
no
E.C.
4.1.2.29
Synonyms
iolJ, fbaB, yxdI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0191 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,073,081 4,073,953
The protein
Catalyzed reaction/ biological activity
6-phospho-5-dehydro-2-deoxy-D-gluconate --> 3-oxopropanoate + dihydroxyacetone phosphate (according to UniProt)
Protein family
class II fructose-bisphosphate aldolase family (with FbaA, according to UniProt)
Structure
4TO8 (PDB) (from Staphylococcus aureus, 56% identity) PubMed
Effectors of protein activity
inhibited by alpha-keto acids PubMed
Paralogous protein(s)
Expression and Regulation
Operons
Biological materials
Mutant
MGNA-B701 (iolJ::erm), available at the NBRP B. subtilis, Japan
Labs working on this gene/protein
Yasutaro Fujita, University of Fukuyama, Japan
[[Ken-ichi Yoshida]], Kobe University, Japan
References
Structural and functional characterization of methicillin-resistant Staphylococcus aureus's class IIb fructose 1,6-bisphosphate aldolase.
Biochemistry. 2014 Dec 09; 53(48):7604-14. doi:10.1021/bi501141t. PMID:25390935
myo-Inositol catabolism in Bacillus subtilis.
The Journal of biological chemistry. 2008 Apr 18; 283(16):10415-24. doi:10.1074/jbc.M708043200. PMID:18310071
myo-Inositol catabolism in Bacillus subtilis.
The Journal of biological chemistry. 2008 Apr 18; 283(16):10415-24. doi:10.1074/jbc.M708043200. PMID:18310071
Interaction of a repressor and its binding sites for regulation of the Bacillus subtilis iol divergon.
Journal of molecular biology. 1999 Jan 22; 285(3):917-29. . PMID:9887260
Organization and transcription of the myo-inositol operon, iol, of Bacillus subtilis.
Journal of bacteriology. 1997 Jul; 179(14):4591-8. . PMID:9226270
Page visits: 5911
Time of last update: 2025-04-09 12:42:35
Author of last update: Melvin.boenninger