fliW
168
checkpoint protein for hag expression, CsrA antagonist
Locus
BSU_35380
Molecular weight
16.03 kDa
Isoelectric point
4.34
Function
control of CsrA activity
Product
flagellar assembly factor, CsrA antagonist
Essential
no
Synonyms
fliW, yviF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1699 (Galperin et al., 2021)
This gene is a member of the following regulons
SigA regulon, SigD regulon, ComK regulon, DegU regulon, ScoC regulon
Gene
Coordinates
3,636,264 3,636,695
The protein
Catalyzed reaction/ biological activity
Protein family
fliW family (single member, according to UniProt)
Structure
5DMD (PDB) (from Geobacillus thermodenitrificans) PubMed
cytoplasm (according to Swiss-Prot)
Additional information
Expression and Regulation
Operons
Description
Expression
expression is heterogeneous PubMed
Regulatory mechanism
Sigma factors
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Biological materials
Mutant
MGNA-A339 (yviF::erm), available at the NBRP B. subtilis, Japan
References
Reviews
The structure and regulation of flagella in Bacillus subtilis.
Annual review of genetics. 2014; 48:319-40. doi:10.1146/annurev-genet-120213-092406. PMID:25251856
Post-transcriptional regulation on a global scale: form and function of Csr/Rsm systems.
Environmental microbiology. 2013 Feb; 15(2):313-24. doi:10.1111/j.1462-2920.2012.02794.x. PMID:22672726
Original Publications
Protein complexes in cells by AI-assisted structural proteomics.Molecular systems biology. 2023 Feb 23; :e11544. PMID: 36815589
Contact with the CsrA core is required for allosteric inhibition by FliW in Bacillus subtilis.Journal of bacteriology. 2020 Oct 26; . PMID: 33106347
Robust Stoichiometry of FliW-CsrA Governs Flagellin Homeostasis and Cytoplasmic Organization in Bacillus subtilis.
mBio. 2019 May 21; 10(3). pii:e00533-19. doi:10.1128/mBio.00533-19. PMID:31113895
Structural basis for the CsrA-dependent modulation of translation initiation by an ancient regulatory protein.
Proceedings of the National Academy of Sciences of the United States of America. 2016 Sep 06; 113(36):10168-73. doi:10.1073/pnas.1602425113. PMID:27551070
FliW antagonizes CsrA RNA binding by a noncompetitive allosteric mechanism.
Proceedings of the National Academy of Sciences of the United States of America. 2016 Aug 30; 113(35):9870-5. doi:10.1073/pnas.1602455113. PMID:27516547
An experimentally supported model of the Bacillus subtilis global transcriptional regulatory network.
Molecular systems biology. 2015 Nov 17; 11(11):839. doi:10.15252/msb.20156236. PMID:26577401
FliW and FliS function independently to control cytoplasmic flagellin levels in Bacillus subtilis.
Journal of bacteriology. 2013 Jan; 195(2):297-306. doi:10.1128/JB.01654-12. PMID:23144244
CsrA-FliW interaction governs flagellin homeostasis and a checkpoint on flagellar morphogenesis in Bacillus subtilis.
Molecular microbiology. 2011 Oct; 82(2):447-61. doi:10.1111/j.1365-2958.2011.07822.x. PMID:21895793
Novel conserved assembly factor of the bacterial flagellum.
Journal of bacteriology. 2006 Nov; 188(21):7700-6. . PMID:16936039
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Time of last update: 2025-01-17 01:34:35
Author of last update: Jstuelk