tdk

tdk
168

thymidine kinase

Locus
BSU_37060
Molecular weight
21.30 kDa
Isoelectric point
5.69
Protein length
195 aaSequenceBlast
Gene length
588 bpSequenceBlast
Function
biosynthesis of thymidine nucleotides
Product
thymidine kinase (ATP:thymidine)
Essential
no
E.C.
2.7.1.21
Synonyms
tdk
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1435 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,802,405 → 3,802,992
The protein
Catalyzed reaction/ biological activity
ATP + thymidine --> ADP + dTMP + H+ (according to UniProt)
Protein family
thymidine kinase family (single member, according to UniProt)
Structure
2JA1 (PDB) (from B. cereus, 69% identity) PubMed
Q03221 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Biological materials
Mutant
BKE37060 (Δtdk::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAGGCTTCGCTCCCCTCT,  downstream forward: _UP4_TAGTCCAAAACATGGGTATA
BKK37060 (Δtdk::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAGGCTTCGCTCCCCTCT,  downstream forward: _UP4_TAGTCCAAAACATGGGTATA
References
Research papers
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Time of last update: 2025-04-09 10:56:37

Author of last update: Melvin.boenninger