purF
168
glutamine phosphoribosyldiphosphate amidotransferase
Locus
BSU_06490
Molecular weight
51.45 kDa
Isoelectric point
5.87
Function
purine biosynthesis
Product
glutamine phosphoribosyldiphosphate amidotransferase
Essential
no
E.C.
2.4.2.14
Synonyms
purF, purB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0034 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
705,441 706,871
The protein
Catalyzed reaction/ biological activity
5-phospho-β-D-ribosylamine + diphosphate + L-glutamate --> 5-phospho-α-D-ribose 1-diphosphate + H2O + L-glutamine (according to UniProt)
Protein family
Purine/pyrimidine phosphoribosyltransferase family (according to UniProt)
Glutamine amidotransferase type-2 domain (aa 12-231) (according to UniProt)
Fe-S cluster PubMed
Structure
1GPH (PDB), 1AO0 (PDB) (complex with ADP and GMP)
Additional information
subject to Clp-dependent proteolysis upon glucose starvation PubMed
Expression and Regulation
Operons
Description
Regulation
expression activated by glucose (4.4 fold) PubMed
Regulatory mechanism
Sigma factors
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Biological materials
Mutant
References
Reviews
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Original Publications
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Time of last update: 2025-01-24 08:17:21
Author of last update: Melvin.boenninger