Difference between revisions of "MhqR"
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− | * '''Description:''' | + | * '''Description:''' MarR-family transcriptional repressor of ''[[azoR2]]'', ''[[mhqA]]'', ''[[mhqD]]-[[mhqE]]'' and ''[[mhqN]]-[[mhqO]]-[[mhqP]]'' expression <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Gene name''' | |style="background:#ABCDEF;" align="center"|'''Gene name''' | ||
− | |'' | + | |''mhqR '' |
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' | + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ykvE'' |
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"| '''Essential''' || | + | |style="background:#ABCDEF;" align="center"| '''Essential''' || no |
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || MarR-family transcriptional repressor |
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of resistance to quinones and diamide |
+ | |- | ||
+ | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13670 mhqR] | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 6.42 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 6.42 | ||
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 435 bp, 145 aa | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 435 bp, 145 aa | ||
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || | + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[kinD]]'', ''[[motB]]'' |
|- | |- | ||
− | |style="background:#FAF8CC;" align="center"|'''[http:// | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13670 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13670 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13670 DNA_with_flanks] |
− | |||
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:ykvE_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ykvE_context.gif]] | ||
+ | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
+ | |- | ||
+ | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mhqR_1433199_1433636_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:mhqR_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13670]] | ||
|- | |- | ||
|} | |} | ||
__TOC__ | __TOC__ | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | |||
<br/><br/> | <br/><br/> | ||
+ | |||
+ | = [[Categories]] containing this gene/protein = | ||
+ | {{SubtiWiki category|[[transcription factors and their control]]}}, | ||
+ | {{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}} | ||
+ | |||
+ | = This gene is a member of the following [[regulons]] = | ||
+ | |||
+ | =The [[MhqR regulon]]= | ||
+ | |||
+ | * ''[[azoR2]]'', ''[[mhqA]]'', ''[[mhqD]]-[[mhqE]]'' and ''[[mhqN]]-[[mhqO]]-[[mhqP]]'' | ||
=The gene= | =The gene= | ||
Line 35: | Line 55: | ||
=== Basic information === | === Basic information === | ||
− | * ''' | + | * '''Locus tag:''' BSU13670 |
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
+ | |||
+ | * '''resistant to quinones and diamide''' | ||
=== Database entries === | === Database entries === | ||
+ | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13670&redirect=T BSU13670] | ||
− | * '''DBTBS entry:''' | + | * '''DBTBS entry:''' no entry |
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13310] | * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13310] | ||
=== Additional information=== | === Additional information=== | ||
− | |||
=The protein= | =The protein= | ||
Line 70: | Line 92: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
− | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
− | * '''Localization:''' | + | * '''[[Localization]]:''' |
=== Database entries === | === Database entries === | ||
+ | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13670&redirect=T BSU13670] | ||
* '''Structure:''' | * '''Structure:''' | ||
− | * ''' | + | * '''UniProt:''' [http://www.uniprot.org/uniprot/O31672 O31672] |
− | * '''KEGG entry:''' | + | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU13670] |
* '''E.C. number:''' | * '''E.C. number:''' | ||
=== Additional information=== | === Additional information=== | ||
− | + | * '''Binding site:''' tATCTcgaAtTCgAGATaaaa {{PubMed|17725564}} | |
=Expression and regulation= | =Expression and regulation= | ||
* '''Operon:''' | * '''Operon:''' | ||
+ | |||
+ | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mhqR_1433199_1433636_1 mhqR] {{PubMed|22383849}} | ||
* '''Sigma factor:''' | * '''Sigma factor:''' | ||
Line 96: | Line 121: | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
− | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Line 113: | Line 138: | ||
=Labs working on this gene/protein= | =Labs working on this gene/protein= | ||
+ | |||
+ | [[Haike Antelmann]],University of Greifswald, Germany | ||
=Your additional remarks= | =Your additional remarks= | ||
Line 118: | Line 145: | ||
=References= | =References= | ||
− | + | =Reviews= | |
+ | |||
+ | <pubmed>18282125</pubmed> | ||
+ | |||
+ | =Original articles= | ||
+ | |||
+ | <pubmed>17725564,, </pubmed> | ||
+ | |||
+ | [[Category:Protein-coding genes]] |
Latest revision as of 13:33, 2 April 2014
- Description: MarR-family transcriptional repressor of azoR2, mhqA, mhqD-mhqE and mhqN-mhqO-mhqP expression
Gene name | mhqR |
Synonyms | ykvE |
Essential | no |
Product | MarR-family transcriptional repressor |
Function | regulation of resistance to quinones and diamide |
Gene expression levels in SubtiExpress: mhqR | |
MW, pI | 16 kDa, 6.42 |
Gene length, protein length | 435 bp, 145 aa |
Immediate neighbours | kinD, motB |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
transcription factors and their control, resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The MhqR regulon
The gene
Basic information
- Locus tag: BSU13670
Phenotypes of a mutant
- resistant to quinones and diamide
Database entries
- BsubCyc: BSU13670
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- BsubCyc: BSU13670
- Structure:
- UniProt: O31672
- KEGG entry: [2]
- E.C. number:
Additional information
- Binding site: tATCTcgaAtTCgAGATaaaa PubMed
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Haike Antelmann,University of Greifswald, Germany
Your additional remarks
References
Reviews
Original articles
Stefanie Töwe, Montira Leelakriangsak, Kazuo Kobayashi, Nguyen Van Duy, Michael Hecker, Peter Zuber, Haike Antelmann
The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis.
Mol Microbiol: 2007, 66(1);40-54
[PubMed:17725564]
[WorldCat.org]
[DOI]
(P p)