tepA

tepA
168

orphan ClpP-like germination protease, contributes to SASP degradation

Locus
BSU_16790
Molecular weight
24.10 kDa
Isoelectric point
5.57
Protein length
245 aaSequenceBlast
Gene length
738 bpSequenceBlast
Function
degradation of SASPs
Product
germination protease
Essential
no
Synonyms
tepA, ymfB, ylxI
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0740 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,751,201  1,751,938
The protein
Catalyzed reaction/ biological activity
degradation of SASPs in germinating spores PubMed
Protein family
Peptidase S14 family (with ClpP, according to UniProt)
Structure
Q99171 (AlphaFold)
Effectors of protein activity
activity requires YlzJ PubMed
Localization
inner spore membrane PubMed
Expression and Regulation
Operons
Genes
tepA-ylzJ
Description
PubMed
Regulation
expressed late during sporulation in the forespore (SigG, SpoVT) PubMed
Regulatory mechanism
SpoVT: repression, PubMed, in spoVT regulon
Sigma factors
SigG: sigma factor, PubMed, in sigG regulon
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tepA→ylzJ

2025-03-07 01:26:46

ghost

77

881067a6f0a1afd8c17c21d46442823bbbcc221d

65C3CDB44DB233763F0B479582509A5F32BD4D75

Biological materials
Mutant
MGNA-B377 (ymfB::erm), available at the NBRP B. subtilis, Japan
GP1120 (spc), available in Jörg Stülke's lab
BKE16790 (tepA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTCGCTTTCATCCTTTC,  downstream forward: _UP4_AAAGAAGAAGGACGGATGAT
BKK16790 (tepA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTCGCTTTCATCCTTTC,  downstream forward: _UP4_AAAGAAGAAGGACGGATGAT
References
Reviews
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Original Publications
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A16C6515D185E3A268D57D77F28EF7EF9AF9FE05

Page visits: 3141

Time of last update: 2025-04-09 13:34:03

Author of last update: Jstuelk