bdbC

bdbC
168

thiol-disulfide oxidoreductase, required for the formation of thiol disulfide bonds in several proteins

Locus
BSU_33470
Molecular weight
15.57 kDa
Isoelectric point
9.05
Protein length
Gene length
Function
oxidative folding of proteins
Product
thiol-disulfide oxidoreductase
Essential
no
E.C.
null
Synonyms
bdbC, yvgU

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1495 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,437,644  3,438,060
Phenotypes of a mutant
loss of transformability PubMed
sensitive to osmotic shock PubMed
several proteins are absent from the membrane proteome of a ''bdbC-bdbD'' mutant: PubMed
the membrane proteins BglP, TcyP, SipU, LytA, and YxaI PubMed
the cytoplasmic or membrane-associated proteins GlkX, ProA, PyrAA, PyrAB, PyrH, PyrE, PyrF, DegS, EcfA1 PubMed
The protein
Catalyzed reaction/ biological activity
formation of thiol disulfide bonds in ComEC and ComGC (together with BdbD) PubMed
oxidative folding of SunA (together with BdbB)
Protein family
DsbB family (with BdbB, according to UniProt)
Structure
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
Description
Regulation
expressed early during sporulation in the mother cell (SigE) PubMed
Regulatory mechanism
ComK: activation, PubMed, in comK regulon
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
Open in new tab

bdbDbdbC

2025-01-23 22:33:26

ghost

87

b9f9957f01263287ae582242bf32ab2011d0ab98

375946244898BBA2C85E094CE97AB311DF1A954B

Biological materials
Mutant
GP4235 (ΔbdbC::kan), available in Jörg Stülke's lab
GP4246 (ΔbdbC::cat), available in Jörg Stülke's lab
MGNA-B603 (yvgU::erm), available at the NBRP B. subtilis, Japan
BKE33470 (bdbC::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATATTGTTACTTCCCTTTC,  downstream forward: _UP4_TAACAAAAAAAGCGCCCGCG
BKK33470 (bdbC::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATATTGTTACTTCCCTTTC,  downstream forward: _UP4_TAACAAAAAAAGCGCCCGCG
References
Reviews
Loading
Original Publications
Loading

A01637E1BFABA20A2923BA85A25CCD8A0D665F78

Page visits: 3812

Time of last update: 2025-01-27 12:31:53

Author of last update: MBenda