minD
168

cell division inhibitor (septum placement), part of the Min system (with Z ring placement), required for the disassembly of polar Z rings after cell division

Locus

BSU_27990

Molecular weight

29.26 kDa

Isoelectric point

4.98

Protein length

268 aaSequenceBlast

Gene length

807 bpSequenceBlast

Function

septum placement

Product

cell division inhibitor

Essential

Synonyms

minD, divIVB1

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2894 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

2,857,776 2,858,582

Phenotypes of a mutant

produces minicells PubMed

increased cell length PubMed

a whiA minC-minD mutant grows poorly, and the cells are filamentous PubMed

severe growth defect of a minD noc double mutant at increased temperature (37°C or above) due to a maturation defect of the Z-ring for cell division, this can be suppressed by any mutation affecting the ClpX-ClpP-SpxH proteolytic system due to Spx-mediated increased expression of ZapA PubMed

The protein

Catalyzed reaction/ biological activity

The Min system prevents minicell formation adjacent to recently completed division sites by promoting the disassembly of the cytokinetic ring, thereby ensuring that cell division occurs only once per cell cycle PubMed

required for oriC placement during spore development PubMed

Protein family

ParA family (with FlhG and ParA, according to UniProt)

Structure

4V03 (PDB) (from Aquifex aeolicus, 51% identity) PubMed

Q01464 (AlphaFold)

Localization

polar/septal at the cell membrane PubMed

membrane binding/polar localization depends on the proton motive force PubMed

Additional information

about 3,500 molecules per cell PubMed

Expression and Regulation