efp

efp
168

elongation factor P, important for the Translation of proteins containing three or more consecutive proline residues

Locus
BSU_24450
Molecular weight
20.31 kDa
Isoelectric point
4.84
Protein length
185 aaSequenceBlast
Gene length
558 bpSequenceBlast
Function
Translation
Product
elongation factor P
Essential
no
Synonyms
efp, yqhU, yqgF
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0231 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,538,115  2,538,672
Phenotypes of a mutant
defective in Swarming motility PubMed
inactivation of ''efp'' reduces sporulation efficiency to 1% that of wild type cells PubMed
an efp yfmR double mutant is not viable PubMed
The protein
Catalyzed reaction/ biological activity
see a list of Efp-dependent proteins
Protein family
elongation factor P family (single member, according to UniProt)
Structure
6RK3 (PDB) (from Staphylococcus aureus, 71% identity) PubMed
P49778 (AlphaFold)
Modification
carries a 5-aminopentanol moiety at Lys-32, this modification is essential for activity PubMed
Localization
cytoplasm (according to Swiss-Prot)
Additional information
subject to Clp-dependent proteolysis upon glucose starvation PubMed
Expression and Regulation
Operons
Genes
figP-yqhS-papA-efp
Description
PubMed
Open in new tab

figP→efp

2025-03-16 14:07:56

Jstuelk

109

5a3af415b3d477ed26b5a5ba683e8b71aa900cda

4C13A03AFAA21B82D13D48369D7EA262D08E39DE

Genes
yqhS-papA-efp
Description
PubMed
Open in new tab

yqhS→efp

2025-03-08 20:01:54

Jstuelk

109

04645919ad54957aa4b00016a6391e23f3845b46

AAFB82DFDDF37319D77CE472A297D3AA713E6311

Biological materials
Mutant
MGNA-C464 (efp::erm), available at the NBRP B. subtilis, Japan
BKE24450 (''efp::erm'', available in the BGSC and in Jörg Stülke's lab) PubMed
BKE24450 (efp::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTTAATGTCCTCCTAT,  downstream forward: _UP4_TAGAAAGAAAAAAAGAAGTC
BKK24450 (efp::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTTAATGTCCTCCTAT,  downstream forward: _UP4_TAGAAAGAAAAAAAGAAGTC
References
Reviews
Loading
Original Publications
Loading

3054CD45713BBD69C2A528DE24AF6AF37175FD9D

Page visits: 5133

Time of last update: 2025-04-09 09:04:36

Author of last update: Jstuelk