trpF

trpF
168

phosphoribosylanthranilate isomerase

Locus
BSU_22650
Molecular weight
23.91 kDa
Isoelectric point
8.37
Protein length
Gene length
Function
biosynthesis of tryptophan
Product
phosphoribosylanthranilate isomerase
Essential
no
E.C.
5.3.1.24
Synonyms
trpF

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0135 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,373,487 → 2,374,134
The protein
Catalyzed reaction/ biological activity
N-(5-phospho-β-D-ribosyl)anthranilate --> 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (according to UniProt)
Protein family
TrpF family (single member, according to UniProt)
Structure
1DL3 (PDB) (from Thermotoga maritima, 33% identity) PubMed
Expression and Regulation
Operons
Description
Regulation
not expressed if tryptophan is available (MtrB) PubMed
the mRNA is substantially stabilized upon depletion of RNase Y PubMed
the RNA switch RNA is degraded by RNase Y PubMed
Regulatory mechanism
MtrB: transcription termination, PubMed, in mtrB regulon
Open in new tab

trpEtrpA

2025-01-10 20:08:59

Jstuelk

77

53eef6e8739e58d1bed57b78e584c86a2e6ff379

37D11B58C2266E362D5C193ADEA68D53F64A90E3

Description
Regulation
not expressed if tryptophan is available (MtrB) PubMed
the mRNA is substantially stabilized upon depletion of RNase Y PubMed
Regulatory mechanism
MtrB: transcription termination, PubMed, in mtrB regulon
Open in new tab

trpEaroE

2025-01-15 09:59:21

Jstuelk

104

a3b37416002f0f1e65847bd8d15ba18b53400752

AA88BDB7192FA5467301E36C102EEEBB21BEDA86

Biological materials
Mutant
BKE22650 (ΔtrpF::erm  trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TTTTAATGCCGGTTTCTTCA,  downstream forward: _UP4_CTTTTAGAAGAAAGGATGAA
BKK22650 (ΔtrpF::kan  trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TTTTAATGCCGGTTTCTTCA,  downstream forward: _UP4_CTTTTAGAAGAAAGGATGAA
References
Reviews
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Original Publications
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C6872585F9BD3717A4F49E96F7684C4A5AD1760D

Page visits: 3324

Time of last update: 2025-01-17 12:00:34

Author of last update: Melvin.boenninger