gerKB
168

nutrient receptor

Locus

BSU_03720

Molecular weight

41.61 kDa

Isoelectric point

8.92

Protein length

373 aaSequenceBlast

Gene length

1122 bpSequenceBlast

Function

germination

Product

part of the putative nutrient-gated GerKA-GerKB-GerKC ion channel

Essential

Synonyms

gerKB

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5902 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

422,982 → 424,103

The protein

Catalyzed reaction/ biological activity

the GerKA-GerKB-GerKC ion channel likely releases ions from the spore core in response to asparagine, glucose, fructose and K⁺ to trigger Germination, this requires the gerB locus PubMed

Protein family

amino acid-polyamine-organocation (APC) superfamily (according to UniProt)

Spore germination protein (SGP) (TC 2.A.3.9) family (according to UniProt)

Structure

P49940 (AlphaFold)

Paralogous protein(s)

GerBB, GerAB, YndE

Localization

spore inner membrane PubMed

Expression and Regulation

Operons

Genes

gerKA-gerKC-gerKB

Description

PubMed

Regulation

expressed during sporulation (SigG, SpoVT) PubMed

Regulatory mechanism

SpoVT: repression, PubMed, in spoVT regulon

Sigma factors

SigG: sigma factor, PubMed, in sigG regulon

Additional information

700 molecules are present per spore PubMed

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Biological materials

Mutant

BKE03720 (ΔgerKB::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCTGTCACTTCCCCTTTC, downstream forward: _UP4_TGATAAAAAGAGCGGGGGGA

BKK03720 (ΔgerKB::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCTGTCACTTCCCCTTTC, downstream forward: _UP4_TGATAAAAAGAGCGGGGGGA

References

Reviews

Original Publications

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Time of last update: 2025-03-13 07:33:58

Author of last update: Jstuelk

gerKB 168

gerKB
168