yvcT

yvcT
168

similar to hydroxypyruvate reductase

Locus
BSU_34680
Molecular weight
36.46 kDa
Isoelectric point
5.09
Protein length
Gene length
Function
unknown
Product
unknown
Essential
no
E.C.
1.1.1.215
Synonyms
yvcT

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1052 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,562,566 → 3,563,543
The protein
Catalyzed reaction/ biological activity
D-gluconate + NADP+ --> 2-dehydro-D-gluconate + H+ + NADPH (according to UniProt)
Protein family
D-isomer specific 2-hydroxyacid dehydrogenase family (with YoaD and SerA, according to UniProt)
Structure
5AOV (PDB) (from Pyrococcus furiosus, 46% identity) PubMed
Additional information
The gene is annotated in KEGG as gluconate 2-dehydrogenase EC 1.1.1.215. The gene is marked “similar to glycerate dehydrogenase” in MetaCyc and marked as probable EC 1.1.1.215 in Swiss-Prot. No literature/experimental evidence supporting the annotation is available.  PubMed
Expression and Regulation
Operons
Genes
Description
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yvcT

2025-01-17 21:12:24

Jstuelk

71

b40b8602c5351d8693555add9ca90143917d28fb

F70576B8DA139E2FE8500B173B242FD975120F8B

Biological materials
Mutant
MGNA-B633 (yvcT::erm), available at the NBRP B. subtilis, Japan
BKE34680 (ΔyvcT::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CAAGGCTCCCCCTTTATGGC,  downstream forward: _UP4_TAAATCAAAAATCCGGTCTG
BKK34680 (ΔyvcT::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CAAGGCTCCCCCTTTATGGC,  downstream forward: _UP4_TAAATCAAAAATCCGGTCTG
References
Research papers
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Page visits: 2460

Time of last update: 2025-01-17 15:32:43

Author of last update: Jstuelk