gpsB
168

cell cycle regulator, cytosolic adaptor for multiple cell wall enzymes, required for removal of PBP1 from the cell pole after completion of cell pole maturation

Locus

BSU_22180

Molecular weight

11.45 kDa

Isoelectric point

5.63

Protein length

98 aaSequenceBlast

Gene length

297 bpSequenceBlast

Function

cell division, cell elongation, spatiotemporal control of penicillin‐binding protein activity

Product

cell division adaptor protein, member of the divisome

Essential

Synonyms

gpsB, ypsB

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3599 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

2,331,779 → 2,332,075

Phenotypes of a mutant

synthetic lethal phenotype with a ''ftsA'' mutation PubMed; synthetic sick phenotype when combined with an ''ezrA'' mutation PubMed, although this seems controversial PubMed

reduced growth at high salt PubMed

The protein

Catalyzed reaction/ biological activity

activates PrkC PubMed

Protein family

GpsB family (single member, according to UniProt)

Domains

contains a DivIVA-like N-terminal lipid binding domain PubMed

Structure

4UG3 (PDB) (N-terminal domain, aa 1-68) PubMed

5AN5 (PDB) (C-terminal domain, aa 76-98) PubMed

GpsB is hexameric (trimer of dimers) PubMed