gpr

gpr
168

germination protease (degradation of SASPs)

Locus
BSU_25540
Molecular weight
40.12 kDa
Isoelectric point
5.2
Protein length
368 aaSequenceBlast
Gene length
1107 bpSequenceBlast
Function
degradation of SASPs
Product
germination protease (degradation of SASPs)
Essential
no
Synonyms
gpr
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5911 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,634,505  2,635,611
The protein
Catalyzed reaction/ biological activity
degradation of small, acid-soluble spore proteins (SASPs) PubMed
Endopeptidase action with P4 Glu or Asp, P1 preferably Glu > Asp, P1' hydrophobic and P2' Ala (according to UniProt)
Protein family
peptidase A25 family (single member, according to UniProt)
Structure
1C8B (PDB) (from B. megaterium, 68% identity) PubMed
P22322 (AlphaFold)
Localization
inner spore membrane PubMed
Expression and Regulation
Operons
Genes
gpr-spoIIP
Description
PubMed
Regulation
expressed during sporulation in the forespore (SigF, SigG, SpoVT) PubMed
Regulatory mechanism
SpoVT: repression, PubMed, in spoVT regulon
Sigma factors
SigF: sigma factor, PubMed, in sigF regulon
SigG: sigma factor, PubMed, in sigG regulon
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gpr→spoIIP

2025-04-03 20:20:00

Jstuelk

95

76a8c0a73904216fb84776d2606465c8bd587731

DC8A669EDBB0F070BE63D7364C4DD18943FA2867

Biological materials
Mutant
BKE25540 (gpr::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACAGGGGCCTCCTTCAC,  downstream forward: _UP4_TAAACAGTTCTACTTCCTCT
BKK25540 (gpr::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACAGGGGCCTCCTTCAC,  downstream forward: _UP4_TAAACAGTTCTACTTCCTCT
References
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Time of last update: 2025-04-05 18:19:05

Author of last update: Jstuelk