hutI

hutI
168

imidazolone-5-propionate hydrolase

Locus
BSU_39370
Molecular weight
45.40 kDa
Isoelectric point
5.22
Protein length
421 aaSequenceBlast
Gene length
1266 bpSequenceBlast
Function
histidine utilization
Product
imidazolone-5-propionate hydrolase
Essential
no
E.C.
3.5.2.7
Synonyms
hutI
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1228 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,045,245 → 4,046,510
The protein
Catalyzed reaction/ biological activity
4-imidazolone-5-propanoate + H2O --> N-formimidoyl-L-glutamate (according to UniProt)
Protein family
Metallo-dependent hydrolases superfamily (according to UniProt)
Structure
2BB0 (PDB) PubMed
P42084 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
hutP-hutH-hutU-hutI-hutG-hutM
Description
PubMed
Regulation
induced by histidine (HutP) PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
CodY: repression, PubMed, in codY regulon
HutP: antitermination, at a protein-dependent RNA switch located between hutP and hutH PubMed, in hutP regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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hutP→hutM

2025-04-03 13:30:05

ghost

154

cf3eb91928f3fe61cbc0cd204535c4f9c144314a

0AE45FCE38B0E774CFFC5F6A0A98EEDF6B02F4D4

Biological materials
Mutant
BKE39370 (ΔhutI::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTGCTTTGGCATGTCATCAC,  downstream forward: _UP4_GTTGTCAACAGGGAGGGAGC
BKK39370 (ΔhutI::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTGCTTTGGCATGTCATCAC,  downstream forward: _UP4_GTTGTCAACAGGGAGGGAGC
References
Reviews
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Original Publications
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BD3382760B704972A0E67ECEDA4B29AA4ECD8164

Page visits: 4301

Time of last update: 2025-04-08 16:18:07

Author of last update: Melvin.boenninger