bacD
168
alanine-anticapsin ligase
Locus
BSU_37710
Molecular weight
52.10 kDa
Isoelectric point
4.68
Function
biosynthesis of the antibiotic bacilysin
Product
alanine-anticapsin ligase
Essential
no
E.C.
6.3.2.28
Synonyms
bacD, ywfE, ipa-83d
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0439 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,870,668 3,872,086
Phenotypes of a mutant
a bacD point mutation has been isolated upon selction at low pressure PubMed
The protein
Catalyzed reaction/ biological activity
ligation of anticapsin to L-Ala to form bacilysin, ultimate step in bacilysin biosynthesis PubMed
ATP + L-alanine + L-anticapsin --> ADP + bacilysin + H+ + phosphate (according to UniProt)
ATP-grasp doamin (aa 142-355) (according to UniProt)
Structure
Expression and Regulation
Operons
Description
Regulation
heterogeneous expression, percentage of expressing cells increases during colonization of plant roots PubMed
Regulatory mechanism
Sigma factors
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Biological materials
Mutant
MGNA-B241 (ywfE::erm), available at the NBRP B. subtilis, Japan
References
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Time of last update: 2025-02-28 19:25:16
Author of last update: Melvin.boenninger