acdA

acdA
168

acyl-CoA dehydrogenase

Locus
BSU_37170
Molecular weight
41.29 kDa
Isoelectric point
4.95
Protein length
379 aaSequenceBlast
Gene length
1140 bpSequenceBlast
Function
fatty acid degradation
Product
acyl-CoA dehydrogenase
Essential
no
Synonyms
acdA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1960 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,813,246  3,814,385
The protein
Catalyzed reaction/ biological activity
A + 2,3-saturated acyl-CoA --> 2,3-dehydroacyl-CoA + AH2 (according to UniProt)
Protein family
Acyl-CoA dehydrogenase family (according to UniProt)
Cofactors
FAD (according to UniProt)
Structure
2Z1Q (PDB) (from Thermus thermophilus hb8, 40% identity, 55% similarity)
P45867 (AlphaFold)
Paralogous protein(s)
FadE, YngJ, MmgC
Expression and Regulation
Operons
Genes
fadF-acdA-rpoE
Description
PubMed
Regulation
repressed in the absence of long-chain fatty acids (FadR) PubMed
Regulatory mechanism
FadR: repression, PubMed, in fadR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

fadF→rpoE

2025-04-04 22:46:51

Jstuelk

137

404be419ef45bd05929352ef6ba5dc0e434ec1c3

9C9A5D2281D0C2A74A807FF5D3F4169BC992CAFF

Biological materials
Mutant
BKE37170 (acdA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATTCATTGCTTCTCCCCCAT,  downstream forward: _UP4_TAACGGAAAACATCTCTCAG
BKK37170 (acdA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATTCATTGCTTCTCCCCCAT,  downstream forward: _UP4_TAACGGAAAACATCTCTCAG
References
Loading

7D89BBB52403BF99416250688EFA90C2BE8EB591

Page visits: 3082

Time of last update: 2025-04-13 11:47:24

Author of last update: Melvin.boenninger