Difference between revisions of "Metabolism of signalling nucleotides"

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* 2.5.4. [[Nucleotide metabolism/ other]]
 
* 2.5.4. [[Nucleotide metabolism/ other]]
 
|Related=
 
|Related=
−
none
+
* [[DAC domain]]
 +
* [[EAL domain]]
 +
* [[GGDEF domain]]
 
|}}
 
|}}
  
Line 15: Line 17:
 
===ppGpp synthesis and degradation===
 
===ppGpp synthesis and degradation===
 
* [[RelA]]
 
* [[RelA]]
−
* [[YjbM]]
+
* [[SasA]]
−
* [[YwaC]]
+
* [[SasB]]
  
 
===c-di-AMP synthesis===
 
===c-di-AMP synthesis===
 
* [[DisA]]
 
* [[DisA]]
−
* [[YbbP]]
+
* [[CdaA]]
−
* [[YojJ]]
+
* [[CdaS]]
 +
 
 +
=== Control of c-di-AMP synthesis ===
 +
* [[CdaR]] controls [[CdaA]] activity {{PubMed|23192352}}
 +
* [[RadA]] controls [[DisA]] activity {{PubMed|23760274}}
 +
Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well {{PubMed|23192352}}
  
 
===c-di-AMP degradation===
 
===c-di-AMP degradation===
 
* [[GdpP]]
 
* [[GdpP]]
 +
* [[PgpH]]
 +
* [[YfkN]]
 +
 +
===Protein potentially involved in c-di-GMP metabolism and signalling===
  
−
===c-di-GMP degradation (presence of an EAL domain)===
+
==== Proteins containing a [[GGDEF domain]] (potential diguanylate cyclases) ====
−
* [[YkoW]]
+
* [[DgcK]], has cyclase activity
−
* [[YkuI]]
+
* [[DgcW]], has cyclase activity, contains both a GGDEF and an [[EAL domain]]
−
* [[YuxH]]
+
* [[DgcP]], has cyclase activity
 +
* [[YdaK]], no activity, degenerate [[GGDEF domain]]
 +
* [[GdpP]], no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain
  
−
=== c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)===
+
==== Proteins containing an [[EAL domain]] (potential c-di-GMP phosphodiesterases) ====
−
* [[GdpP]]
+
* [[PdeH]], has phosphodiesterase activity
−
* [[YdaK]]
+
* [[YkuI]], no phosphodiesterase activity
−
* [[YhcK]]
+
* [[DgcW]], phosphodiesterase activity not demonstrated, contains both a GGDEF and an [[EAL domain]]
−
* [[YkoW]]
 
−
* [[YtrP]] (this enzyme may be inactive due to the lack of important residues)
 
  
 
=== Targets of signalling nucleotides ===
 
=== Targets of signalling nucleotides ===
 
* ppGpp targets
 
* ppGpp targets
 +
** [[DnaG]]
 
** [[GdpP]]
 
** [[GdpP]]
 +
** [[Gmk]]
 +
** [[GuaB]]
 +
** [[HprT]]
 +
** [[RbgA]]
 +
** [[Era]]
 +
** [[YnbA]]
  
 
* c-di-GMP targets
 
* c-di-GMP targets
−
** [[YpfA]] (contains a PilZ domain)
+
** [[DgrA]] (contains a PilZ domain)
 +
 
 +
* other c-di-GMP-binding proteins
 +
** [[YdaK]]
 +
** [[YkuI]]
 +
 
 +
* c-di-AMP targets
 +
** [[DarA]] {{PubMed|25433025}}
 +
** [[KtrC]] (binds c-di-AMP ''in vivo'') {{PubMed|23671116}}
 +
** the [[ydaO riboswitch]] {{PubMed|24141192}}
  
 
==Important original publications==
 
==Important original publications==
−
<pubmed>21566650</pubmed>
+
<pubmed>21566650 22981860 23192352 23671116 23893111 24141192 24163341 25433025 25605304 26951678 22821967 28965724 </pubmed>
 +
 
 
==Important reviews==
 
==Important reviews==
−
<pubmed>21255104 16045609 17208514 19756011 19287449 18714086</pubmed>
+
<pubmed>21255104 16045609 17208514 19756011 19287449 18714086 23023210 23812326 25636134 25869574,26773214 27354347
 +
    27149325</pubmed>
 +
 
 
=Back to [[categories]]=
 
=Back to [[categories]]=

Latest revision as of 10:10, 3 October 2017

Parent categories
Neighbouring categories
Related categories

Genes in this functional category

ppGpp synthesis and degradation

c-di-AMP synthesis

Control of c-di-AMP synthesis

Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed

c-di-AMP degradation

Protein potentially involved in c-di-GMP metabolism and signalling

Proteins containing a GGDEF domain (potential diguanylate cyclases)

  • DgcK, has cyclase activity
  • DgcW, has cyclase activity, contains both a GGDEF and an EAL domain
  • DgcP, has cyclase activity
  • YdaK, no activity, degenerate GGDEF domain
  • GdpP, no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain

Proteins containing an EAL domain (potential c-di-GMP phosphodiesterases)

  • PdeH, has phosphodiesterase activity
  • YkuI, no phosphodiesterase activity
  • DgcW, phosphodiesterase activity not demonstrated, contains both a GGDEF and an EAL domain

Targets of signalling nucleotides

  • c-di-GMP targets
    • DgrA (contains a PilZ domain)
  • other c-di-GMP-binding proteins

Important original publications

Fabian M Commichau, Johannes Gibhardt, Sven Halbedel, Jan Gundlach, Jörg Stülke
A Delicate Connection: c-di-AMP Affects Cell Integrity by Controlling Osmolyte Transport.
Trends Microbiol: 2018, 26(3);175-185
[PubMed:28965724] [WorldCat.org] [DOI] (I p)

Rebecca M Corrigan, Lauren E Bellows, Alison Wood, Angelika Gründling
ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria.
Proc Natl Acad Sci U S A: 2016, 113(12);E1710-9
[PubMed:26951678] [WorldCat.org] [DOI] (I p)

Anthony O Gaca, Cristina Colomer-Winter, José A Lemos
Many means to a common end: the intricacies of (p)ppGpp metabolism and its control of bacterial homeostasis.
J Bacteriol: 2015, 197(7);1146-56
[PubMed:25605304] [WorldCat.org] [DOI] (I p)

Jan Gundlach, Achim Dickmanns, Kathrin Schröder-Tittmann, Piotr Neumann, Jan Kaesler, Jan Kampf, Christina Herzberg, Elke Hammer, Frank Schwede, Volkhard Kaever, Kai Tittmann, Jörg Stülke, Ralf Ficner
Identification, characterization, and structure analysis of the cyclic di-AMP-binding PII-like signal transduction protein DarA.
J Biol Chem: 2015, 290(5);3069-80
[PubMed:25433025] [WorldCat.org] [DOI] (I p)

Allison Kriel, Shaun R Brinsmade, Jessica L Tse, Ashley K Tehranchi, Alycia N Bittner, Abraham L Sonenshein, Jue D Wang
GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes.
J Bacteriol: 2014, 196(1);189-201
[PubMed:24163341] [WorldCat.org] [DOI] (I p)

James W Nelson, Narasimhan Sudarsan, Kazuhiro Furukawa, Zasha Weinberg, Joy X Wang, Ronald R Breaker
Riboswitches in eubacteria sense the second messenger c-di-AMP.
Nat Chem Biol: 2013, 9(12);834-9
[PubMed:24141192] [WorldCat.org] [DOI] (I p)

Xiaohui Gao, Sampriti Mukherjee, Paige M Matthews, Loubna A Hammad, Daniel B Kearns, Charles E Dann
Functional characterization of core components of the Bacillus subtilis cyclic-di-GMP signaling pathway.
J Bacteriol: 2013, 195(21);4782-92
[PubMed:23893111] [WorldCat.org] [DOI] (I p)

Rebecca M Corrigan, Ivan Campeotto, Tharshika Jeganathan, Kevin G Roelofs, Vincent T Lee, Angelika Gründling
Systematic identification of conserved bacterial c-di-AMP receptor proteins.
Proc Natl Acad Sci U S A: 2013, 110(22);9084-9
[PubMed:23671116] [WorldCat.org] [DOI] (I p)

Felix M P Mehne, Katrin Gunka, Hinnerk Eilers, Christina Herzberg, Volkhard Kaever, Jörg Stülke
Cyclic di-AMP homeostasis in bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth.
J Biol Chem: 2013, 288(3);2004-17
[PubMed:23192352] [WorldCat.org] [DOI] (I p)

Allison Kriel, Alycia N Bittner, Sok Ho Kim, Kuanqing Liu, Ashley K Tehranchi, Winnie Y Zou, Samantha Rendon, Rui Chen, Benjamin P Tu, Jue D Wang
Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance.
Mol Cell: 2012, 48(2);231-41
[PubMed:22981860] [WorldCat.org] [DOI] (I p)

Yun Chen, Yunrong Chai, Jian-hua Guo, Richard Losick
Evidence for cyclic Di-GMP-mediated signaling in Bacillus subtilis.
J Bacteriol: 2012, 194(18);5080-90
[PubMed:22821967] [WorldCat.org] [DOI] (I p)

Yaara Oppenheimer-Shaanan, Ezequiel Wexselblatt, Jehoshua Katzhendler, Eylon Yavin, Sigal Ben-Yehuda
c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis.
EMBO Rep: 2011, 12(6);594-601
[PubMed:21566650] [WorldCat.org] [DOI] (I p)


Important reviews


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