Difference between revisions of "Metabolism of signalling nucleotides"
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* 2.5.4. [[Nucleotide metabolism/ other]] | * 2.5.4. [[Nucleotide metabolism/ other]] | ||
|Related= | |Related= | ||
| − | + | * [[DAC domain]] | |
| + | * [[EAL domain]] | ||
| + | * [[GGDEF domain]] | ||
|}} | |}} | ||
| Line 15: | Line 17: | ||
===ppGpp synthesis and degradation=== | ===ppGpp synthesis and degradation=== | ||
* [[RelA]] | * [[RelA]] | ||
| − | * [[ | + | * [[SasA]] |
| − | * [[ | + | * [[SasB]] |
===c-di-AMP synthesis=== | ===c-di-AMP synthesis=== | ||
* [[DisA]] | * [[DisA]] | ||
| − | * [[ | + | * [[CdaA]] |
| − | * [[ | + | * [[CdaS]] |
| + | |||
| + | === Control of c-di-AMP synthesis === | ||
| + | * [[CdaR]] controls [[CdaA]] activity {{PubMed|23192352}} | ||
| + | * [[RadA]] controls [[DisA]] activity {{PubMed|23760274}} | ||
| + | Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well {{PubMed|23192352}} | ||
===c-di-AMP degradation=== | ===c-di-AMP degradation=== | ||
* [[GdpP]] | * [[GdpP]] | ||
| + | * [[PgpH]] | ||
| + | * [[YfkN]] | ||
| + | |||
| + | ===Protein potentially involved in c-di-GMP metabolism and signalling=== | ||
| − | === | + | ==== Proteins containing a [[GGDEF domain]] (potential diguanylate cyclases) ==== |
| − | * [[ | + | * [[DgcK]], has cyclase activity |
| − | * [[ | + | * [[DgcW]], has cyclase activity, contains both a GGDEF and an [[EAL domain]] |
| − | * [[ | + | * [[DgcP]], has cyclase activity |
| + | * [[YdaK]], no activity, degenerate [[GGDEF domain]] | ||
| + | * [[GdpP]], no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain | ||
| − | === c-di-GMP | + | ==== Proteins containing an [[EAL domain]] (potential c-di-GMP phosphodiesterases) ==== |
| − | * [[ | + | * [[PdeH]], has phosphodiesterase activity |
| − | * [[ | + | * [[YkuI]], no phosphodiesterase activity |
| − | * [[ | + | * [[DgcW]], phosphodiesterase activity not demonstrated, contains both a GGDEF and an [[EAL domain]] |
| − | |||
| − | |||
=== Targets of signalling nucleotides === | === Targets of signalling nucleotides === | ||
* ppGpp targets | * ppGpp targets | ||
| + | ** [[DnaG]] | ||
** [[GdpP]] | ** [[GdpP]] | ||
| + | ** [[Gmk]] | ||
| + | ** [[GuaB]] | ||
| + | ** [[HprT]] | ||
| + | ** [[RbgA]] | ||
| + | ** [[Era]] | ||
| + | ** [[YnbA]] | ||
* c-di-GMP targets | * c-di-GMP targets | ||
| − | ** [[ | + | ** [[DgrA]] (contains a PilZ domain) |
| + | |||
| + | * other c-di-GMP-binding proteins | ||
| + | ** [[YdaK]] | ||
| + | ** [[YkuI]] | ||
| + | |||
| + | * c-di-AMP targets | ||
| + | ** [[DarA]] {{PubMed|25433025}} | ||
| + | ** [[KtrC]] (binds c-di-AMP ''in vivo'') {{PubMed|23671116}} | ||
| + | ** the [[ydaO riboswitch]] {{PubMed|24141192}} | ||
==Important original publications== | ==Important original publications== | ||
| − | <pubmed>21566650</pubmed> | + | <pubmed>21566650 22981860 23192352 23671116 23893111 24141192 24163341 25433025 25605304 26951678 22821967 28965724 </pubmed> |
| + | |||
==Important reviews== | ==Important reviews== | ||
| − | <pubmed>21255104 16045609 17208514 19756011 19287449 18714086</pubmed> | + | <pubmed>21255104 16045609 17208514 19756011 19287449 18714086 23023210 23812326 25636134 25869574,26773214 27354347 |
| + | 27149325</pubmed> | ||
| + | |||
=Back to [[categories]]= | =Back to [[categories]]= | ||
Latest revision as of 10:10, 3 October 2017
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Contents
- 1 Genes in this functional category
- 2 Important original publications
- 3 Important reviews
- 4 Back to categories
Genes in this functional category
ppGpp synthesis and degradation
c-di-AMP synthesis
Control of c-di-AMP synthesis
Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed
c-di-AMP degradation
Protein potentially involved in c-di-GMP metabolism and signalling
Proteins containing a GGDEF domain (potential diguanylate cyclases)
- DgcK, has cyclase activity
- DgcW, has cyclase activity, contains both a GGDEF and an EAL domain
- DgcP, has cyclase activity
- YdaK, no activity, degenerate GGDEF domain
- GdpP, no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain
Proteins containing an EAL domain (potential c-di-GMP phosphodiesterases)
- PdeH, has phosphodiesterase activity
- YkuI, no phosphodiesterase activity
- DgcW, phosphodiesterase activity not demonstrated, contains both a GGDEF and an EAL domain
Targets of signalling nucleotides
- c-di-GMP targets
- DgrA (contains a PilZ domain)
Important original publications
Important reviews
