khpA
168
putative RNA chaperone
Locus
BSU_16000
Molecular weight
8.93 kDa
Isoelectric point
7.34
Function
unknown
Product
putative RNA chaperone
Essential
no
E.C.
null
Synonyms
ylqC, KhpA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1837 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,673,892 1,674,137
The protein
Protein family
UPF0109 family (single member, according to UniProt)
KH domain (aa 34-81) (according to UniProt)
Structure
Expression and Regulation
Operons
Description
Regulation
expression is reduced in motile cells as compared to non-motile cells PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
Biological materials
Mutant
MGNA-B173 (ylqC::erm), available at the NBRP B. subtilis, Japan
Expression vectors
pGP3616 expression of khpA-Strep by pGP382 in B. subtilis suitable for SPINE, available in Jörg Stülke's lab
Reviews
Small proteins in Gram-positive bacteria.FEMS microbiology reviews. 2023 Nov 1; 47(6). PMID: 38052429
Understudied proteins and understudied functions in the model bacterium Bacillus subtilis-A major challenge in current research.Molecular microbiology. 2023 Mar 7; . PMID: 36882621
KH-domain proteins: another family of bacterial RNA matchmakers?Molecular microbiology. 2021 Nov 8; . PMID: 34748246
References
Effect of tRNA Maturase Depletion on Levels and Stabilities of Ribosome Assembly Cofactor and Other mRNAs in Bacillus subtilis.Microbiology spectrum. 2023 Feb 22; :e0513422. PMID: 36840557
Cloning and characterization of a Bacillus subtilis gene encoding a homolog of the 54-kilodalton subunit of mammalian signal recognition particle and Escherichia coli Ffh.
Journal of bacteriology. 1993 Aug; 175(15):4885-94. . PMID:8335643
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Time of last update: 2025-01-17 17:12:13
Author of last update: Jstuelk