speA

speA
168

arginine decarboxylase, required for biofilm formation

Locus
BSU_14630
Molecular weight
53.42 kDa
Isoelectric point
5.08
Protein length
Gene length
Function
spermidine, polyamine biosynthesis
Product
arginine decarboxylase
Essential
no
E.C.
4.1.1.19
Synonyms
speA, cad

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1982 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,534,279 → 1,535,751
Phenotypes of a mutant
The protein
Catalyzed reaction/ biological activity
H+ + L-arginine --> agmatine + CO2 (according to UniProt)
Protein family
Orn/Lys/Arg decarboxylase class-I family (together with YaaO) (according to UniProt)
PLP (according to UniProt)
Structure
2X3L (PDB) (from Staphylococcus aureus, 28% identity) PubMed
Paralogous protein(s)
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
Description
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speA

2025-01-16 05:23:25

Jstuelk

63

ad6c8f56db9062e9c83fbac0dc85f9dfaf893a6e

CC7E9F958C18D17DDF7417E194F5FCE20FCC8311

Biological materials
Mutant
CS210 (''speA::aphA3'', available in Colin Harwood's and Jörg Stülke's labs) PubMed
BKE14630 (ΔspeA::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CAATTGTTTTCCCACCTTTG,  downstream forward: _UP4_TAAAAAATAAAAAGCATGCG
BKK14630 (ΔspeA::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CAATTGTTTTCCCACCTTTG,  downstream forward: _UP4_TAAAAAATAAAAAGCATGCG
References
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Time of last update: 2025-01-22 17:18:16

Author of last update: Jstuelk