groEL

groEL
168

chaperonin and co-repressor for HrcA

Locus
BSU_06030
Molecular weight
57.25 kDa
Isoelectric point
4.53
Protein length
Gene length
Function
protein folding and re-folding
Product
chaperonin, co-repressor for HrcA
Essential
yes
Synonyms
groEL, groL

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0459 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
650,234 651,868
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
acts as co-repressor for HrcA
Protein family
chaperonin (HSP60) family (single member, according to UniProt)
Structure
1WE3 (PDB) (GroEL-GroES complex from Thermus thermophilus, 65% identity) PubMed
Modification
phosphorylated on Arg-35, Arg-116, and Arg-282 PubMed
phosphorylated on ser/ thr/ tyr PubMed, PubMed
cytoplasm (according to Swiss-Prot)
recruited to the membrane after ethanol stress PubMed
Additional information
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Description
Regulation
induced by heat shock (HrcA) PubMed
Regulatory mechanism
HrcA: repression, PubMed, in hrcA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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groESgroEL

2025-01-20 16:14:55

ghost

103

7fb6158ced0e9ff3d6f6587b1fd32ed77da6f183

AC98D4758A8163DB8CD3EEE6A0A4E85819251D63

Biological materials
Expression vectors
for expression, purification in E. coli with N-terminal His-tag, in pWH844: pGP1000 available in Jrg Stlke's lab
for expression, purification in E. coli with N-terminal Strep-tag, in pGP172: pGP1002 available in Jrg Stlke's lab
References
Reviews
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Original Publications
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8F3DEE8828CA6BAAAF6DB2DA4349EF7AA9DF89F8

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Time of last update: 2025-01-23 05:27:22

Author of last update: Jstuelk