gntZ

gntZ
168

6-phosphogluconate dehydrogenase

Locus
BSU_40080
Molecular weight
51.82 kDa
Isoelectric point
4.76
Protein length
Gene length
Function
gluconate utilization
Product
6-phosphogluconate dehydrogenase
Essential
no
E.C.
1.1.1.44
Synonyms
gntZ

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0362 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,117,080  4,118,486
The protein
Catalyzed reaction/ biological activity
6-phospho-D-gluconate + NAD+ --> CO2 + D-ribulose 5-phosphate + NADH (according to UniProt)
Protein family
6-phosphogluconate dehydrogenase family (with YqeC and GndA, according to UniProt)
Structure
2W8Z (PDB) (from Geobacillus stearothermophilus, 58% identity) PubMed
Paralogous protein(s)
Expression and Regulation
Operons
Description
Regulation
induced by gluconate (GntR) PubMed
Regulatory mechanism
GntR: repression, PubMed, in gntR regulon
CcpA: repression, PubMed, in ccpA regulon
AbrB: activation, PubMed, in abrB regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

gntRgntZ

2025-01-22 22:23:03

ghost

73

a4a9f34acee86d883fafe2368089737d1c13df10

02F8B40AEEBB8D4A2614150F30482A3F72134EF4

Genes
Description
Regulation
induced by gluconate (GntR) PubMed
Open in new tab

gntZ

2025-01-18 23:06:57

ghost

53

e374cc752780f5f890ae0f8338a20e7be30db1eb

3AE1B5774A2C97DAFCC00B50E9A7BB322BAD0E53

Biological materials
Mutant
MGNA-B679 (gntZ::erm), available at the NBRP B. subtilis, Japan
BKE40080 (gntZ::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATGTGTTACAGCTCCTTCT,  downstream forward: _UP4_TAACCTGTATTAAAAACACG
BKK40080 (gntZ::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATGTGTTACAGCTCCTTCT,  downstream forward: _UP4_TAACCTGTATTAAAAACACG
References
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7E7187AA2DC172018A63A7B9CE48124F30311639

Page visits: 3234

Time of last update: 2025-01-23 23:24:27

Author of last update: Melvin.boenninger