aspS

aspS
168

aspartyl-tRNA synthetase

Locus
BSU_27550
Molecular weight
65.80 kDa
Isoelectric point
4.65
Protein length
592 aaSequenceBlast
Gene length
1779 bpSequenceBlast
Function
translation
Product
aspartyl-tRNA synthetase
Essential
yes
E.C.
6.1.1.12
Synonyms
aspS
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0173 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,814,743 2,816,521
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
ATP + L-aspartate + tRNAAsx --> AMP + diphosphate + L-aspartyl-tRNAAsx (according to UniProt)
Protein family
Class-II aminoacyl-tRNA synthetase family (according to UniProt)
Structure
1EQR (PDB) (from Escherichia coli, 52% identity, 68% similarity) PubMed
O32038 (AlphaFold)
Modification
phosphorylated on ser/ thr/ tyr PubMed
Additional information
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Genes
hisS-aspS
Regulation
induced by histidine or aspartate limitation (T-box) PubMed
the T-box RNA is degraded by RNase Y PubMed
Regulatory mechanism
T-box: RNA switch, via tRNA controlled RNA switch, in T-box
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hisS→aspS

2025-03-15 12:15:29

Jstuelk

88

93588a5ea574db697b96bea0c2bb438af53f1051

2E078F834F39052D1FF1E957F712D4887C9079D3

References
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2B61D17950ADE0247B0CF4AE33548E15C0DDCD9B

Page visits: 4601

Time of last update: 2025-04-06 05:03:29

Author of last update: Melvin.boenninger