iolA
168
methylmalonate-semialdehyde dehydrogenase (acylating)
Locus
BSU_39760
Molecular weight
53.29 kDa
Isoelectric point
5.14
Function
myo-inositol catabolism
Product
methylmalonate-semialdehyde dehydrogenase (acylating)
Essential
no
E.C.
1.2.1.27
Synonyms
iolA, mmsA, yxdA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1012 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,082,920 4,084,383
The protein
Catalyzed reaction/ biological activity
NAD-dependent oxidation of methylmalonate semialdehyde (MMSA) to propionyl-CoA via acylation and deacylation steps
3-oxopropanoate + CoA + NAD+ --> acetyl-CoA + CO2 + NADH (according to UniProt)
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ --> H+ + hydrogencarbonate + NADH + propanoyl-CoA (according to UniProt)
Protein family
aldehyde dehydrogenase family (according to UniProt)
Coenzyme A, NAD PubMed
Structure
Paralogous protein(s)
Expression and Regulation
Operons
Biological materials
Mutant
MGNA-B770 (iolA::erm), available at the NBRP B. subtilis, Japan
Labs working on this gene/protein
Yasutaro Fujita, University of Fukuyama, Japan
[[Ken-ichi Yoshida]], Kobe University, Japan
References
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Time of last update: 2025-01-18 15:05:59
Author of last update: Melvin.boenninger