hepS
168
heptaprenyl diphosphate synthase component I
locus
BSU_22760
Molecular weight
28.97 kDa
pI
6.27
function
menaquinone biosynthesis
product
heptaprenyl diphosphate synthase component I (together with [protein|3CAEA54E80A0B56EE120B881C8CDBE055AF6BDC1|hepT])
essential
no
ec
2.5.1.30
synonyms
hepS, gerCA, hepA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
2,383,615 → 2,384,370
Phenotypes of a mutant
the mutant tends to acquire suppressor mutations that result in improved growth [Pubmed|28189581]
essential [Pubmed|12682299], non-essential according to [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate --> all-trans-heptaprenyl diphosphate + 4 diphosphate (according to UniProt)
Structure
[AF|P31112]
Expression and Regulation
Operons
genes
[gene|C45A5935559F0DAAD70F808725AF730BC18A2B0A|hepS]-[gene|DDD40AEBBCBD3C19661A72B85912E266DBF267B3|menH]-[gene|3CAEA54E80A0B56EE120B881C8CDBE055AF6BDC1|hepT]-[gene|B498ED03F19B7A73878D5C947C28C2A87CAB934D|ndk]
description
[pubmed|22383849]
Biological materials
Mutant
BKE22760 (Δ[gene|C45A5935559F0DAAD70F808725AF730BC18A2B0A|hepS]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAAATATCACCCTTGTCC, downstream forward: _UP4_TAAACCATTATGCAGGACTC
BKK22760 (Δ[gene|C45A5935559F0DAAD70F808725AF730BC18A2B0A|hepS]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAAATATCACCCTTGTCC, downstream forward: _UP4_TAAACCATTATGCAGGACTC
References
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Time of last update: 2025-01-19 19:42:16
Author of last update: Christoph.elfmann