sdaAB

sdaAB
168

L-serine deaminase

Locus
BSU_15850
Molecular weight
23.67 kDa
Isoelectric point
5.1
Protein length
220 aaSequenceBlast
Gene length
663 bpSequenceBlast
Function
serine utilization
Product
L-serine deaminase (beta chain)
Essential
no
E.C.
4.3.1.17
Synonyms
sdaAB, yloW, sdaA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1760 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,658,242 → 1,658,904
Phenotypes of a mutant
overexpression of sdaAB-sdaAA results in resistance to serine PubMed
The protein
Catalyzed reaction/ biological activity
L-serine --> NH4+ + pyruvate (according to UniProt)
Protein family
iron-sulfur dependent L-serine dehydratase family (with SdaAA, according to UniProt)
Domains
ACT domain (aa 148-220) (according to UniProt)
Cofactors
Fe-S cluster PubMed
Structure
O34635 (AlphaFold)
Expression and Regulation
Operons
Genes
sdaAB-sdaAA-recG
Description
PubMed
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sdaAB→recG

2025-03-17 16:50:07

Jstuelk

108

75880fc7bd1a3984391d66dc804deda756b8db43

B3C473F399334F3F232E4FA23EE6A4A24E3A8838

Biological materials
Mutant
BKE15850 (ΔsdaAB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCTATTCCTCCTTATGA,  downstream forward: _UP4_TAGCGAAAAGGGTCAGGAGG
BKK15850 (ΔsdaAB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCTATTCCTCCTTATGA,  downstream forward: _UP4_TAGCGAAAAGGGTCAGGAGG
LacZ fusion
pGP2275 (in pAC5) (GP2967), available in Jörg Stülke's lab PubMed
References
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BC19D5B3764503298ED7136FC9F63A68F6AC464F

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Time of last update: 2025-04-09 10:29:01

Author of last update: Jstuelk