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| − | {{CategoryTree
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| − | |Parents=
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| − | * 1. [[Cellular processes]]
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| − | ** 1.2. [[Transporters]]
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| − | |Neighbours=
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| − | * 1.2.1. [[ABC transporters]]
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| − | * 1.2.2. [[Phosphotransferase systems]]
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| − | * 1.2.3. [[Transporters/ other]]
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| − | |Related=
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| − | * [[PRD-containing transcription factors]]
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| − | * [[transport proteins]]
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| − | * [[trigger enzymes]]
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| − | |}}
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| | | | |
| − | __TOC__
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| − | <br><br>
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| − | =The PEP:Sugar Phosphotransferase System=
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| − | '''The PTS is a sugar transport system that couples the transport of a sugar to its phosphorylation. The phosphate group is derived from phosphoenolpyruvate (PEP) and transferred via the general PTS proteins [[ptsI|Enzyme I]] ([[ptsI|EI]]) and [[ptsH|HPr]] to the substrate-specific Enzymes II (EII) to the incoming sugars.'''
| + | [[File:Example.jpg]] |
| − | | |
| − | '''In addition to its role in sugar transport, the PTS is also involved in the regulation of carbon metabolism.'''
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| − | | |
| − | ==General PTS proteins==
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| − | * [[ptsI|Enzyme I]]
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| − | * [[ptsH|HPr]]
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| − | | |
| − | ==Sugar specific PTS proteins==
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| − | * [[PtsG]]: glucose permease, EIICBA
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| − | * [[GamP]]: glucosamine permease, EIICBA
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| − | * [[MurP]]: N-acetyl muramic acid-specific phosphotransferase system, EIIBC component
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| − | * [[MtlA]], [[MtlF]]: mannitol permease
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| − | * [[GmuA]], [[GmuB]], [[GmuC]]: galactomannan permease
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| − | * [[TreP]]: trehalose permease
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| − | * [[MalP]]: maltose permease
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| − | * [[FruA]]: fructose permease
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| − | * [[ManP]]: mannose permease
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| − | * [[NagP]]: N-acetylglucosamine permease, EIICB component
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| − | * [[LevD]], [[LevE]], [[LevF]], [[LevG]]: fructose permease
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| − | * [[SacP]]: sucrose permease (high affinity)
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| − | * [[SacY]]: sucrose permease (low affinity)
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| − | * [[LicA]], [[LicB]], [[LicC]]: lichenan permease
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| − | * [[BglP]]: ß-glucoside permease
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| − | * [[YpqE]]: unknown EIIA component
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| − | * [[YwbA]]: unknown EIIC component
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| − | * [[YyzE]]: unknown PTS protein
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| − | | |
| − | ==Proteins closely related to the PTS==
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| − | * [[Crh]]: [[ptsH|HPr]]-like protein with exculsively regulatory functions (His-15 is not conserved
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| − | * [[HprK]]: [[ptsH|HPr]]-kinase, key factor for carbon catabolite repression
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| − | | |
| − | ==Non-PTS proteins controlled by PTS-dependent phosphorylation==
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| − | * [[PRD-containing transcription factors]]
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| − | * [[GlpK]]
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| − | | |
| − | ==The PTS in [[SubtiPathways|''Subti''Pathways]]==
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| − | * [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]
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| − | * [http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]
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| − | | |
| − | ==Relevant Reviews==
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| − | <pubmed>17158705 9871918 9663674 10627040 11532441 16339738 </pubmed>
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| − | | |
| − | == Genes in this functional category ==
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| − | * [[murP]]
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| − | * [[gamP]]
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| − | * [[mtlA]]
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| − | * [[mtlF]]
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| − | * [[gmuB]]
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| − | * [[gmuA]]
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| − | * [[gmuC]]
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| − | * [[nagP]]
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| − | * [[treP]]
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| − | * [[malP]]
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| − | * [[manP]]
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| − | * [[ptsG]]
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| − | * [[ptsH]]
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| − | * [[ptsI]]
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| − | * [[fruA]]
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| − | * [[ypqE]]
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| − | * [[levG]]
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| − | * [[levF]]
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| − | * [[levE]]
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| − | * [[levD]]
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| − | * [[sacP]]
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| − | * [[ywbA]]
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| − | * [[sacX]]
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| − | * [[licA]]
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| − | * [[licC]]
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| − | * [[licB]]
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| − | * [[bglP]]
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| − | * [[yyzE]]
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