brxC

brxC
168

monothiol bacilliredoxin, general stress protein

Locus
BSU_29760
Molecular weight
12.26 kDa
Isoelectric point
5.09
Protein length
108 aaSequenceBlast
Gene length
327 bpSequenceBlast
Function
removal of bacillithiol from oxidized cytosolic proteins
Product
monothiol bacilliredoxin
Essential
no
Synonyms
ytxJ, csb40
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
3,046,757  3,047,083
The protein
Catalyzed reaction/ biological activity
removal of bacilliredoxin from oxidized cytosolic proteins, including the glyceraldehyde 3-phosphate dehydrogenases GapA and GapB PubMed
Protein family
Trx family
Domains
contains a single conserved Cys residue in a motif (TCPIS) reminiscent of that found in monothiol glutaredoxins PubMed
Structure
3IV4 (PDB) (from Staphylococcus aureus, 41% identity)
P39914 (AlphaFold)
Modification
phosphorylation on (Thr-93 OR Ser-94 OR Ser-96 OR Thr-99) PubMed
Expression and Regulation
Operons
Genes
facZ-ytxH-brxC
Description
PubMed
Regulation
induced by stress (SigB) PubMed
Sigma factors
SigB: sigma factor, PubMed, in sigB regulon
SigH: sigma factor, PubMed, in sigH regulon
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facZ→brxC

2025-03-31 02:16:02

ghost

112

a0db108502ded191eef0405d77d786ae7bc7abdc

623E0B035BA1319C480A20A9385612A917A73D50

Biological materials
Mutant
MGNA-B527 (ytxJ::erm), available at the NBRP B. subtilis, Japan
BKE29760 (brxC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGACTCAAGCTCTTCCTT,  downstream forward: _UP4_TAGAAAAAAGCGTCCAGATA
BKK29760 (brxC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGACTCAAGCTCTTCCTT,  downstream forward: _UP4_TAGAAAAAAGCGTCCAGATA
References
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Time of last update: 2025-04-15 21:01:22

Author of last update: Jstuelk