cmoO

cmoO
168

monooxygenase, required for the conversion of S-methyl-cysteine to cysteine

Locus
BSU_29330
Molecular weight
36.79 kDa
Isoelectric point
5.84
Protein length
334 aaSequenceBlast
Gene length
1005 bpSequenceBlast
Function
utilization of S-methyl-cysteine
Product
monooxygenase
Essential
no
Synonyms
cmoO, ytmO
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2141 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,003,345 → 3,004,349
Phenotypes of a mutant
no growth with S-methyl cysteine PubMed
The protein
Protein family
Flavin-utilizing monoxygenases
Cofactors
FMN PubMed
Structure
4US5 (PDB) (from Streptomyces bottropensis, 31% identity) PubMed
O34846 (AlphaFold)
Paralogous protein(s)
YwcH, YvbT
YceB, (37,4%)
Expression and Regulation
Operons
Genes
snaA-tcyJ-tcyK-tcyL-tcyM-tcyN-cmoO-cmoI-cmoJ-ribR-sndA-ytnM
Description
PubMed
Regulation
induced in the presence of methionine and taurine PubMed
Regulatory mechanism
CymR: repression, PubMed, in cymR regulon
AscR: activation, PubMed, in ascR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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snaA→ytnM

2025-03-22 23:22:48

Jstuelk

115

8a3868e633778d2f68bf47d615f22f716e843294

4D6CA410A1DC104A491D3C18248CCD50CC0E983A

Biological materials
Mutant
MGNA-A174 (ytmO::erm), available at the NBRP B. subtilis, Japan
BKE29330 (ΔcmoO::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTGGTCTAAAATACTTAAGC,  downstream forward: _UP4_AAACGTTAAGGAGGGACAGA
BKK29330 (ΔcmoO::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTGGTCTAAAATACTTAAGC,  downstream forward: _UP4_AAACGTTAAGGAGGGACAGA
References
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EDC3565D90D7059A4A4C66A13EB568420F6CECD4

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Time of last update: 2025-04-09 15:53:39

Author of last update: Jstuelk