thiG
168

hydroxyethylthiazole phosphate biosynthesis

Locus

BSU_11690

Molecular weight

26.87 kDa

Isoelectric point

4.72

Protein length

256 aaSequenceBlast

Gene length

771 bpSequenceBlast

Function

biosynthesis of thiamine

Product

thiamin thiazole synthase

Essential

E.C.

null

Synonyms

thiG, yjbT

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2022 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,245,041 → 1,245,811

The protein

Catalyzed reaction/ biological activity

1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH₂-C(O)SH --> 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H⁺ + 2 H₂O (according to UniProt)

Protein family

ThiG family (single member, according to UniProt)

Structure

1XM3 (PDB), 1TYG (PDB) (complex with ThiS) PubMed

O31618 (AlphaFold)

Modification

phosphorylated on ser/ thr/ tyr PubMed, PubMed

Localization

cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

Genes