epeX

epeX
168

competition determinant, secreted linear antimicrobial peptide, controls LiaR-LiaS activity

Locus
BSU_40180
Molecular weight
5.65 kDa
Isoelectric point
9.57
Protein length
49 aaSequenceBlast
Gene length
150 bpSequenceBlast
Function
conpetition with other bacteria, control of LiaR-LiaS activity
Product
secreted antimicrobial peptide
Essential
no
Synonyms
yydF
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
4,127,498 → 4,127,647
The protein
Structure
Q45596 (AlphaFold)
Modification
modified (epimerization of Val-36 and Ile-44 to the D-forms) by the radical SAM epimerase EpeE PubMed
processing to the mature modified peptide (epipeptide) by the membrane protease EpeP PubMed
Localization
extracellular (processing requires EpeP, transport by EpeA-EpeB) PubMed
Expression and Regulation
Operons
Genes
epeX-epeE-epeP-epeA-epeB
Description
PubMed
Regulation
repressed during logarithmic growth (AbrB) PubMed
Expression
expression is heterogeneous PubMed
Regulatory mechanism
AbrB: repression, PubMed, in abrB regulon
Rok: repression, PubMed, in rok regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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epeX→epeB

2025-03-30 23:00:09

Jstuelk

101

078981D5A4F256B0FA27157DFABCDDE534EC3306

BE1247045A413B93C3150C913C43B4E1B8098926

Additional information
the mRNA is very stable (> 15 min) PubMed
the epeX portion of the mRNA belongs to the most stable mRNAs in B. subtilis PubMed
Biological materials
Mutant
BKE40180 (ΔepeX::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTATCCCTCCTCCTTT,  downstream forward: _UP4_TAATTAGAGGGGTACAAAGG
BKK40180 (ΔepeX::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTATCCCTCCTCCTTT,  downstream forward: _UP4_TAATTAGAGGGGTACAAAGG
References
Reviews
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Original Publications
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D66B9BFF79ADD8B0F9BFA3892FCF4597264CE9EE

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Time of last update: 2025-04-02 19:58:44

Author of last update: Jstuelk