sunS

sunS
168

phage-derived sublancin S-glycosyltransferase

Locus
BSU_21450
Molecular weight
49.60 kDa
Isoelectric point
5.33
Protein length
422 aaSequenceBlast
Gene length
1269 bpSequenceBlast
Function
biosynthesis of the antimicrobial peptide sublancin
Product
sublancin S-glycosyltransferase
Essential
no
Synonyms
yolJ
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0463 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,265,668  2,266,936
The protein
Catalyzed reaction/ biological activity
selectively modifies Cys22 in a 56-amino acid peptide substrate SunA and can accept a variety of NDP-sugars PubMed
Protein family
glycosyltransferase 2 family (according to UniProt)
Structure
O31986 (AlphaFold)
Expression and Regulation
Operons
Genes
sunA-sunT-bdbA-sunS-bdbB
Description
PubMed
Regulation
repressed by Rok-DnaA PubMed
expression starts in the stationary phase PubMed
expression is heterogeneous in the population, this is mediated by AbrB, Rok, and Spo0A PubMed
Regulatory mechanism
Rok: repression, PubMed, in rok regulon
Abh: activation, PubMed, in abh regulon
DnaA: repression, Rok-DnaA PubMed, in dnaA regulon
YvrHb: activation, PubMed, in yvrHb regulon
AbrB: repression, PubMed, in abrB regulon
Additional information
the mRNA is very stable (> 15 min) PubMed
the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed
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sunA→bdbB

2025-04-13 13:50:14

Jstuelk

118

173a6d1c6c62ab55ab2900d516e97b549076ae97

85D1B8FA2F46C6C22D4D5CAD32F0080E33BACFA0

Biological materials
Mutant
BKE21450 (sunS::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTATCTATCACCATTTTT,  downstream forward: _UP4_GTATGAATACAAGATATGTA
BKK21450 (sunS::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTATCTATCACCATTTTT,  downstream forward: _UP4_GTATGAATACAAGATATGTA
References
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6B2DC9873B7B693D9D0FC0D773740140D0640C9E

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Time of last update: 2025-04-17 04:26:21

Author of last update: Jstuelk