ftsH

ftsH
168

ATP-dependent metalloprotease

Locus
BSU_00690
Molecular weight
70.76 kDa
Isoelectric point
5.84
Protein length
637 aaSequenceBlast
Gene length
1914 bpSequenceBlast
Function
cell division, sporulation initiation
Product
ATP-dependent metalloprotease
Essential
no
Synonyms
ftsH
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0465 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
76,984  78,897
Phenotypes of a mutant
loss of genetic competence PubMed
defective in biofilm formation PubMed
strongly reduced sporulation frequency PubMed, PubMed
The protein
Catalyzed reaction/ biological activity
degrades Spo0E and Spo0M, resulting in reduced sporulation frequency in a ftsH mutant PubMed
FtsH is involved in the degradation of EzrA PubMed
degrades SpoIIE PubMed
Protein family
central section: AAA ATPase family (according to UniProt)
C-terminal section: Peptidase M41 family (single member, according to UniProt)
Structure
1LV7 (PDB) (from E. coli, 64% identity) PubMed
P37476 (AlphaFold)
Effectors of protein activity
protease activity is controlled by the interaction with the flottilins FloA and FloT PubMed
Paralogous protein(s)
YjoB
Localization
cell membrane PubMed
preferentially at the division septum PubMed
forms some foci in the membrane PubMed
Expression and Regulation
Operons
Genes
tilS-hprT-ftsH
Description
PubMed
Regulation
induced by heat shock (class III)
Regulatory mechanism
TilS: activation, with HprT PubMed, in tilS regulon
HprT: activation, with TilS PubMed, in hprT regulon
Sigma factors
SigM: sigma factor, PubMed, in sigM regulon
SigA: sigma factor, PubMed, in sigA regulon
Additional information
the mRNA is very stable (half-life > 15 min) PubMed
Open in new tab

tilS→ftsH

2025-04-04 02:37:40

ghost

102

0b831aee45fd6cc4e3e06cbf53fe7330f12b4cb1

0B2B3D2B74921E6EEF5704482CF1D3DF309FA3D3

Genes
spoIIE-yabS-yabT-tilS-hprT-ftsH
Description
PubMed
Regulation
expressed early during sporulation in the forespore (SigF) PubMed
Sigma factors
SigF: sigma factor, PubMed, in sigF regulon
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spoIIE->ftsH

2025-04-03 08:25:04

Jstuelk

122

7069328a463a18ae1e3c27f03ddf76f79efe7c06

8FBB4B976CF46DAD9437300BBE1B22B618D33ED0

Genes
ftsH
Description
PubMed
Regulation
induced by heat shock (class III)
Additional information
the mRNA is very stable (half-life > 15 min) PubMed
Open in new tab

ftsH

2025-04-04 02:48:16

ghost

112

7e04f0d15d662d6dfeefd5537cf2a5e7778fc26c

DFE2E933DDBA16A1B214B7C055E64EAA42F028A5

Biological materials
Mutant
GP2640 (ΔftsH::aphA3) available in Jörg Stülke's lab PubMed
MGNA-A084 (ftsH::erm), available at the NBRP B. subtilis, Japan
1A1061 ( ftsH::cat), PubMed, available at BGSC
1A1060 ( ftsH::erm), PubMed, available at BGSC
BKE00690 (ftsH::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCCTTACCTCCTCCCAC,  downstream forward: _UP4_TAATTCGCTTTCTTTCTAAA
BKK00690 (ftsH::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCCTTACCTCCTCCCAC,  downstream forward: _UP4_TAATTCGCTTTCTTTCTAAA
Two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jörg Stülke's lab
References
Reviews
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Original Publications
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4E7B9426CED372AA8A321A147116A3A589FBF20C

Page visits: 8667

Time of last update: 2025-04-05 15:33:19

Author of last update: Dennis.wicke