capA

capA
168

gamma-polyglutamate transporter,capsular polyglutamate biosynthesis, involved in controlling the D/L enantiomer ratio in polyglutamate

Locus
BSU_35880
Molecular weight
42.60 kDa
Isoelectric point
9.27
Protein length
380 aaSequenceBlast
Gene length
1143 bpSequenceBlast
Function
capsular polyglutamate biosynthesis
Product
gamma-polyglutamate transporter
Essential
no
Synonyms
capA, ywtB, pgsA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2843 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,697,821  3,698,963
The protein
Protein family
CapA family (with TkmA and EpsA, according to UniProt)
Structure
P96738 (AlphaFold)
Expression and Regulation
Operons
Genes
capB-capC-capA-capE
Description
PubMed
Regulatory mechanism
DegU: activation, DegU-P, PubMed, in degU regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
expression of the operon is increased in 'motA' or 'motB' mutants due to increased DegU phosphorylation PubMed
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capB→capE

2025-03-16 08:50:33

ghost

109

bf6b0bf03353d832d0fb99e09c0c2fcd8af8f057

1302D3190C59C849B9803B3A11C008FA08B67E54

Biological materials
Mutant
MGNA-B121 (pgsA::erm), available at the NBRP B. subtilis, Japan
BKE35880 (capA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCATCGTTTGACACACCT,  downstream forward: _UP4_TCTAAATAATCGGAGTGATA
BKK35880 (capA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCATCGTTTGACACACCT,  downstream forward: _UP4_TCTAAATAATCGGAGTGATA
References
Reviews
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Original Publications
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Time of last update: 2025-04-09 20:55:31

Author of last update: Jstuelk