ptpZ

ptpZ
168

phosphotyrosine protein phosphatase, antagonist to PtkA

Locus
BSU_36240
Molecular weight
28.81 kDa
Isoelectric point
6.66
Protein length
Gene length
Function
protein tyrosine dephosphorylation
Product
phosphotyrosine protein phosphatase, antagonist to PtkA
Essential
no
E.C.
3.1.3.48
Synonyms
ptpZ, ywqE

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4464 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,731,005 → 3,731,769
The protein
Catalyzed reaction/ biological activity
H2O + O-phospho-L-tyrosyl-[protein] --> L-tyrosyl-[protein] + phosphate (according to UniProt)
dephosphorylation of Ugd, TuaD and PtkA PubMed
Protein family
Structure
Expression and Regulation
Operons
Description
Regulatory mechanism
Spo0A: activation, PubMed, in spo0A regulon
DegU: activation, DegU-P, PubMed, in degU regulon
AbrB: repression, PubMed, in abrB regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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tkmAugd

2025-03-17 18:24:39

ghost

105

c2e9da4a42fde0cc0e5b798663a12ae407bf7d28

23621A956181A8BE93792267290B609197EA8EF4

Biological materials
Mutant
MGNA-A077 (ywqE::erm), available at the NBRP B. subtilis, Japan
GP1609 (spc), available in Jörg Stülke's lab
GP1610 (''ptkA-ptpZ'', spc), available in Jörg Stülke's lab
BKE36240 (ΔptpZ::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATGTCCTAGCCCCCTTTTT,  downstream forward: _UP4_TAACAGCCGATTCTCATTTC
BKK36240 (ΔptpZ::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATGTCCTAGCCCCCTTTTT,  downstream forward: _UP4_TAACAGCCGATTCTCATTTC
References
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CF73D86DB024575BE8F043A4C3996458F4262E46

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Time of last update: 2025-04-24 17:52:10

Author of last update: Melvin.boenninger