yidC2

yidC2
168

Sec-independent membrane protein translocase, required for development of genetic competence

Locus
BSU_23890
Molecular weight
30.60 kDa
Isoelectric point
9.9
Protein length
275 aaSequenceBlast
Gene length
828 bpSequenceBlast
Function
membrane insertion of proteins and protein secretion
Product
Sec-independent membrane protein translocase
Essential
no
Synonyms
yidC2, yqjG, oxaAB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0706 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,483,904  2,484,731
The protein
Protein family
OXA1/ALB3/YidC family (with YidC1, according to UniProt) PubMed
Structure
3WO6 (PDB) (from Bacillus halodurans, 41% identity) PubMed
P54544 (AlphaFold)
Paralogous protein(s)
YidC1, one of the two proteins has to be present for viability PubMed
Localization
membrane PubMed
Expression and Regulation
Operons
Genes
mifM-yidC2
Description
PubMed
Regulation
repressed by large amounts of SpoIIIJ, induced by small amounts of SpoIIIJ (MifM) PubMed
Regulatory mechanism
MifM: attenuation, an mRNA hairpin of the yqjG transcript unfold upon translation arrest of MifM at decreased YidC1 levels, in mifM regulon
Additional information
An antisense RNA is predicted for 'mifM' PubMed
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mifM→yidC2

2025-03-10 17:00:28

ghost

113

f8a6fff082045f34969fcbb9e7dd06a79ebdd148

CF4B91E771854E675A6B5052E8B77F0D2D86EFB9

Biological materials
Mutant
MGNA-C389 (yqjG::erm), available at the NBRP B. subtilis, Japan
BKE23890 (yidC2::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATTTTGTTCTCCTCCTTT,  downstream forward: _UP4_TAAAAAAGCAACCCCGTGCA
BKK23890 (yidC2::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATTTTGTTCTCCTCCTTT,  downstream forward: _UP4_TAAAAAAGCAACCCCGTGCA
References
Reviews
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Original Publications
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121A9543F5BC1CBE77D85A34099DE09F8AC63E9F

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Time of last update: 2025-04-11 13:05:12

Author of last update: Jstuelk