noc
168

DNA-binding protein, spatial regulator of cell division to protect the nucleoid, and timing device with an important role in the coordination of chromosome segregation and cell division, Z ring placement, coordination of early steps in DNA replication with establishment of a medial division site

Locus

BSU_40990

Molecular weight

32.64 kDa

Isoelectric point

5.81

Protein length

283 aaSequenceBlast

Gene length

852 bpSequenceBlast

Function

control of cell division

Product

effector of nucleoid occlusion

Essential

Synonyms

noc, yyaA

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1475 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

4,207,897 4,208,748

Phenotypes of a mutant

a whiA noc double mutant grows poorly, and the cells are filamentous PubMed

severe growth defect of a minD noc double mutant at increased temperature (37°C or above) due to a maturation defect of the Z-ring for cell division, this can be suppressed by any mutation affecting the ClpX-ClpP-SpxH proteolytic system due to Spx-mediated increased expression of ZapA PubMed

a refZ noc double mutant is defective in cell division and exhibits reduced sporulation PubMed

The protein

Catalyzed reaction/ biological activity

binds specific sites on the chromosome PubMed

prevents Z ring assembly over the bacterial nucleoid and helps fine tune the assembly of the Z ring at midcell during the cell cycle PubMed

Protein family

ParB family (with ParB, according to UniProt)

Structure

7OL9 (PDB) (C-terminally truncated Noc complexed to the Noc-binding site) PubMed

1VZ0 (PDB) (ParB from Thermus thermophilus, 48% from aa 30 ... 219) PubMed

P37524 (AlphaFold)

Paralogous protein(s)