Difference between revisions of "CotA"

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(Original publications)
(Expression and regulation)
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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:''' ''cotA'' (according to [http://dbtbs.hgc.jp/COG/prom/cotA.html DBTBS])
+
* '''Operon:''' ''cotA'' {{PubMed|22383849}}
  
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=cotA_683462_685003_-1 cotA] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=cotA_683462_685003_-1 cotA] {{PubMed|22383849}}

Revision as of 13:34, 6 April 2015

  • Description: laccase, bilirubin oxidase, spore coat protein (outer)

Gene name cotA
Synonyms pig
Essential no
Product laccase, bilirubin oxidase
Function resistance of the spore
Gene expression levels in SubtiExpress: cotA
MW, pI 58 kDa, 5.89
Gene length, protein length 1539 bp, 513 aa
Immediate neighbours yeaA, gabP
Sequences Protein DNA DNA_with_flanks
Genetic context
CotA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CotA expression.png















Categories containing this gene/protein

sporulation proteins

This gene is a member of the following regulons

GerE regulon, SigK regulon, Efp-dependent proteins

The gene

Basic information

  • Locus tag: BSU06300

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:
  • Localization:
    • outer spore coat, more abundant at the mother cell-distal pole of the forespore, localization depends on CotE PubMed

Database entries

  • Structure: 2BHF (reduced form)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed late during sporulation in the mother cell (SigK, GerE) PubMed
  • Regulatory mechanism:
  • Additional information:
    • translation is likely to require Efp due to the presence of several consecutive proline residues PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Peter T McKenney, Adam Driks, Patrick Eichenberger
The Bacillus subtilis endospore: assembly and functions of the multilayered coat.
Nat Rev Microbiol: 2013, 11(1);33-44
[PubMed:23202530] [WorldCat.org] [DOI] (I p)

Original publications