trmU

trmU
168

tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase, involved in 2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules

Locus
BSU_27500
Molecular weight
42.20 kDa
Isoelectric point
4.73
Protein length
Gene length
Function
tRNA modification
Product
tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase
Essential
yes
E.C.
2.8.1.-
Synonyms
trmU, yrrA, mnmA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0482 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,809,413  2,810,528
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules (together with TrmU) PubMed
U34 in tRNA + L-cysteine + ATP --> (s2U34 in tRNA) + alanine + AMP + ppi PubMed
Protein family
MnmA/TRMU family (single member, according to UniProt)
Structure
2HMA (PDB) (from Streptococcus pneumoniae, 66% identity)
cytoplasm(according to UniProt)
Expression and Regulation
Operons
Description
Open in new tab

cymRrecD2

2025-01-16 13:39:31

Jstuelk

116

abda92d242629b6aea524d43804e9037e28674a8

021F54A200AB704BB82EBD13945C64A7665E25EA

Description
Regulation
RelA dependent downregulation (Class I) during stringent response PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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cymRtrmU

2025-01-16 06:56:38

ghost

141

8c74dd15c62e3038ffc334dd6a5d07145ed7c2d8

DE1A6CEF81820F1A8EA3E9CEE9ECE501D6C33477

References
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2F5DFBE980FFF5810B76BCFCD189BA0F6C415B4F

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Time of last update: 2025-01-17 11:50:05

Author of last update: Jstuelk