trmU
168
tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase, involved in 2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules
Locus
BSU_27500
Molecular weight
42.20 kDa
Isoelectric point
4.73
Function
tRNA modification
Product
tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase
Essential
yes
E.C.
2.8.1.-
Synonyms
trmU, yrrA, mnmA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0482 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
The protein
Catalyzed reaction/ biological activity
2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules (together with TrmU) PubMed
U34 in tRNA + L-cysteine + ATP --> (s2U34 in tRNA) + alanine + AMP + ppi PubMed
Protein family
MnmA/TRMU family (single member, according to UniProt)
Structure
2HMA (PDB) (from Streptococcus pneumoniae, 66% identity)
cytoplasm(according to UniProt)
Expression and Regulation
Operons
Description
Regulation
Regulatory mechanism
stringent response: negative regulation, in stringent response
Sigma factors
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References
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Time of last update: 2025-01-17 11:50:05
Author of last update: Jstuelk